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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: We investigated whether membrane free stem cell extract from adipose tissue (MFSCE) has anti-diabetic effect. Methods: To determine glucose uptake effect of MFSCE, we carried out glucose uptake assay in 3T3-L1 adipocytes. The regulatory mechanisms of MFSCE on glucose uptake were examined by Western blot analysis. Results: When MFSCE was treated to adipocytes at the concentration of 0.5, 1, 2.5, and 5 ㎍/mL, 2-deoxyglucose-6-phosphate uptake was elevated approximately 1.8-fold compared to cells not treated with MFSCE. It indicated that MFSCE enhances glucose uptake in 3T3-L1 adipocytes. In addition, MFSCE reduced phosphorylation of insulin receptor substrate-1 at serine 307 and induced Akt and glucose transporter 4 protein expressions that were related to insulin signaling. Furthermore, MFSCE regulated adenosine monophosphate-activated protein kinase (AMPK) pathway by increases of increase phosphorylation of AMPK and acetyl-CoA carboxylase that were related to AMPK pathway. Conclusions: These results indicated that MFSCE promotes glucose uptake via modulation of insulin signaling and AMPK pathway. Therefore, MFSCE could be a promising agent for treatment of diabetes mellitus.
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참고문헌 (27)
참고문헌 신청
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Ward WK / 1984 / Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus / Diabetes Care 7:491~502
Action to Control Cardiovascular Risk in Diabetes Study Group / 2008 / Effects of intensive glucose lowering in type 2 diabetes / N Engl J Med 358:2545~2559
Bouchoucha M / 2011 / Metformin and digestive disorders / Diabetes Metab 37:90~96
Hussein Z / 2004 / Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital / Med J Aust 181:536~539
Ward WK / 1984 / Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus / Diabetes Care 7:491~502
Action to Control Cardiovascular Risk in Diabetes Study Group / 2008 / Effects of intensive glucose lowering in type 2 diabetes / N Engl J Med 358:2545~2559
Bouchoucha M / 2011 / Metformin and digestive disorders / Diabetes Metab 37:90~96
Hussein Z / 2004 / Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital / Med J Aust 181:536~539
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