개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제7호
- 발행연도
- 2015.1
- 수록면
- 2,785 - 2,791 (7page)
이용수
초록· 키워드
오류제보하기
The purpose of the study was to determine the effects of autophagy related gene Beclin1 at different levels of expression on the sensitivity of cisplatin-resistant ovarian cancer cells (SKOV3/DDP) to different chemotherapeutics. In pSUPER-Beclin1 transfected cells, real-time fluorescence quantitative RT-PCR and Western blot analysis showed that expression was significantly inhibited. Flow cytometry revealed that the mean fluorescence intensity (MDC), reflecting autophagy, and cells in the G0/G1 phase were markedly reduced. When compared with the blank control group, inhibition of Beclin1 expression in SKOV3/DDP cells not only increased the rate of apoptosis following treatment with chemotherapeutics, but also increased the sensitivity. These findings suggest that Beclin1 expression plays an important role in chemotherapeutic agent-induced death of SKOV3/DDP cells. Inhibition of autophagy related gene Beclin1 expression in SKOV3/DDP cells may increase the rate of apoptosis and elevate the sensitivity to chemotherapeutics.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
XIAP Associated Factor 1 (XAF1) Represses Expression of X-linked Inhibitor of Apoptosis Protein (XIAP) and Regulates Invasion, Cell Cycle, Apoptosis, and Cisplatin Sensitivity of Ovarian Carcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Autophagy localization and cytoprotective role in cisplatin-induced acute kidney injury
Korean Journal of Veterinary Research(대한수의학회지)
2019 .10
-
Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
Cancer Research and Treatment
2015 .01
-
Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Autophagy in Tumorigenesis and Cancer Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
Cancer Research and Treatment
2015 .01
-
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
Toxicological Research
2019 .04
-
Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells
Journal of Ginseng Research
2017 .07
-
Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells
International Journal of Oral Biology
2015 .01
-
Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells
Journal of dental anesthesia and pain medicine
2016 .01
-
Rutin induces autophagy in cancer cells
International Journal of Oral Biology
2016 .01
-
Autophagy in the placenta
Obstetrics & Gynecology Science
2017 .01
-
Autophagy and its regulation by ginseng components
Journal of Ginseng Research
2019 .06
-
Autophagy: a lysosomal degradation process for cellular homeostasis and its relationship with oral squamous cell carcinoma
International Journal of Oral Biology
2021 .01
-
Histological Subtype of Ovarian Cancer as a Determinant of Sensitivity to Formamidine Derivatives of Doxorubicin - in Vitro Comparative Studies with SKOV-3 and ES-2 Cancer Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis
International Journal of Oral Biology
2021 .01
-
Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
와송이 인간 백혈병 세포주 THP-1에서 NF-κB 활성 억제와 p38 활성을 통해 세포사멸과 자가포식에 미치는 영향
대한한의학회지
2019 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0