Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases

Rashed, Reham A; Kadry, Dalia Y; Taweel, Maha EL; Abd El Wahab, Nahed; Abd El Hameed, Thoreya

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자료유형: 학술저널

저자정보: Rashed, Reham A (Clinical Pathology, Medicine, National Cancer Institute) Kadry, Dalia Y (Clinical Pathology, Medicine, National Cancer Institute) Taweel, Maha EL (Clinical Pathology, Medicine, National Cancer Institute) Abd El Wahab, Nahed (Clinical Pathology, Medicine, National Cancer Institute) Abd El Hameed, Thoreya (Medical Oncology Department, Medicine, National Cancer Institute)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제17호

발행연도: 2015.1

수록면: 7,875 - 7,882 (8page)

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Background: The objectives of this study were to evaluate the expression of brain and acute leukemia, cytoplasmic (BAALC) gene and erythroblast transformation-specific related gene (ERG) in de novo cases of acute myeloid leukemia (AML) and identify roles in disease progression and outcome. Materials and Methods: This study included 50 newly diagnosed AML patients, along with 10 apparently healthy normal controls. BAALC and ERG expression was detected in the bone marrow of both patients and controls using real-time RT-PCR. Results: BAALC and ERG expression was detected in 52% of cases but not in any controls. There was a statistically significant correlation between BAALC and ERG gene expression and age (p-value=0.004 and 0.019, respectively). No statistical significance was noted for sex, lymphadenopathy, hepatomegaly, splenomegaly, other hematological findings, immunophenotyping and FAB sub-classification except for ERG gene and FAB (p-value=0.058). A statistical significant correlation was found between response to treatment with ERG expression (p-value=0.028) and age (p-value=0.014). A statistically significant variation in overall survival was evident with patient age, BM blast cells, FAB subgroups, BAALC and ERG expression (p-value=<0.001, 0.045, 0.041, <0.008 and 0.025 respectively). Conclusions: Our results suggest that BAALC and ERG genes are specific significant molecular markers in AML disease progression, response to treatment and survival.

#BAALC #ERG #AML #RT-PCR

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