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Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
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논문 기본 정보

Type
Academic journal
Author
Young Bae Choi (아주대학교) YOO KEON HEE (성균관대학교)
Journal
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제2호 KCI Accredited Journals
Published
2022.4
Pages
572 - 578 (7page)
DOI
10.4143/crt.2021.368

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Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
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Purpose Children with Down syndrome (DS) show a higher risk of acute leukemia than those without DS. In this study, we investigated the nationwide incidence of acute leukemia among children with DS and compared their epidemiologic characteristics with those of children with acute leukemia but without DS. Materials and Methods Using the National Health Insurance Service database, we selected patients with acute leukemia aged 0-19 years at diagnosis between 2007 and 2016. Results Among the 4,697 children with acute leukemia, 54 (1.1%) had DS. The median incidence rate of leukemia with DS by year was 1.3% (range, 0.2% to 2.0%). Sixteen patients with acute lymphoblastic leukemia (ALL; 29.6%) and 36 with acute myeloid leukemia (AML; 66.7%) had DS. The DS group showed younger age at diagnosis than the non-DS group, and diagnosis of AML was more frequent in the DS group than in the non-DS group (3 years vs. 9 years, p < 0.001; 66.7% vs. 32.4%, p < 0.001, respectively). The 5-year overall survival was comparable between the DS and non-DS groups (88.0% vs. 81.9%, p=0.375). Among all the Koreans born between 2007 and 2008, the incidences of acute leukemia, ALL, and AML were 49.25, 20.75, and 163.38 times higher, respectively, in the DS group than in the non-DS group. Conclusion Our findings support the fact that the incidence of acute leukemia is higher among patients with DS than among those without DS in Korea. However, the DS and non-DS groups in this study had a comparable overall survival rate.
#Acute leukemia #Precursor cell lymphoblastic leukemia-lymphoma #Acute myeloid leukemia #Childhood #Down syndrome #Lymphoma

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