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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 306 - 315 (10page)
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Background/Aims: The failure to correctly differentiate between intrahepatic cholangiocarcinoma (CC) and hepatocellular carcinoma (HCC) is a significant clinical problem, particularly in terms of the different treatment goals for both cancers. In this study a specific gene expression profile to discriminate these two subgroups of liver cancer was established and potential diagnostic markers for clinical use were analyzed. Methods: To evaluate the gene expression profiles of HCC and intrahepatic CC, Oligonucleotide arrays (AffymetrixU133A) were used. Overexpressed genes were checked for their potential use as new markers for discrimination and their expression values were validated by reverse transcription polymerase chain reaction and immunohistochemistry analyses. Results: 695 genes/expressed sequence tags (ESTs) in HCC (245 up-/450 down-regulated) and 552 genes/ ESTs in CC (221 up-/331 down-regulated) were significantly dysregulated (p<0.05, fold change >2, ≥70%). Using a supervised learning method, and one-way analysis of variance a specific 270-gene expression profile that enabled rapid, reproducible differentiation between both tumors and nonmalignant liver tissues was established. A panel of 12 genes (e.g., HSP90, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers. Conclusions: A specific gene expression profile for discrimination of primary liver cancer was identified and potential marker genes with feasible clinical impact were described.
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참고문헌 (45)
참고문헌 신청
El-Serag HB / 2002 / Hepatocellular carcinoma: an epidemiologic view / J Clin Gastroenterol 35(5 Suppl 2):S72~S78
Davila JA / 2002 / Cholangiocarcinoma: the other liver cancer on the rise / Am J Gastroenterol 97:3199~3200
McGlynn KA / 2001 / International trends and patterns of primary liver cancer / Int J Cancer 94:290~296
El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Yao FY / 2003 / A follow-up analysis of the pattern and predictors of dropout from the waiting list for liver transplantation in patients with hepatocellular carcinoma: implications for the current organ allocation policy / Liver Transpl 9:684~692
Davila JA / 2002 / Cholangiocarcinoma: the other liver cancer on the rise / Am J Gastroenterol 97:3199~3200
McGlynn KA / 2001 / International trends and patterns of primary liver cancer / Int J Cancer 94:290~296
El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Yao FY / 2003 / A follow-up analysis of the pattern and predictors of dropout from the waiting list for liver transplantation in patients with hepatocellular carcinoma: implications for the current organ allocation policy / Liver Transpl 9:684~692
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