MicroRNA-124 rs531564 Polymorphism and Cancer Risk: A Meta-analysis

Li, Wen-Jing; Wang, Yong; Gong, Yu; Tu, Chao; Feng, Tong-Bao; Qi, Chun-Jian

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자료유형: 학술저널

저자정보: Li, Wen-Jing (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital) Wang, Yong (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital) Gong, Yu (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital) Tu, Chao (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital) Feng, Tong-Bao (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital) Qi, Chun-Jian (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제17호

발행연도: 2015.1

수록면: 7,905 - 7,909 (5page)

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Several studies reported there was a polymorphism (rs531564 C > G) in miR-124 gene. To investigate the MiR-124 rs531564 polymorphism and cancer risk. We conducted a literature search of the Medline, Embase and Wangfang Medicine databases to identify all relevant studies for this meta-analysis. We determined that the miR-124 rs531564 polymorphism was significantly associated with decreased risks of cancers in the allelic model (G vs C, OR=0.71, 95% CI=0.53-0.94, P=0.02), homozygote model (GG vs CC, OR=0.42, 95% CI=0.26-0.66, P=0.0002), dominant model (GG/GC vs CC, OR=0.71, 95% CI=0.51-0.98, P=0.04) and recessive model (GG vs GC/CC, OR=0.43, 95% CI=0.27-0.69, P=0.0004). In an analysis stratified by cervical cancer group, significant associations were observed in the allelic model (G vs C, OR=0.46, 95% CI=0.32-0.66, P<0.0001), and dominant model (GG/GC vs CC, OR=0.45, 95% CI=0.3-0.66, P<0.0001). Subgroup analysis also revealed a decreased risk for esophageal squamous cell carcinoma in the homozygote model (GG vs CC, OR=0.45, 95% CI=0.27-0.75, P=0.002) and recessive model (GG vs GC/CC, OR=0.46, 95% CI=0.28-0.75, P=0.002). This meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population.

#miR-124 #rs531564 #polymorphism #cancer risk #meta-analysis

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Li, Wen-Jing

소속기관 Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 Peopl