Anticancer Activity of Atractylodes lancea (Thunb.) DC in a Hamster Model and Application of PET-CT for Early Detection and Monitoring Progression of Cholangiocarcinoma

Plengsuriyakarn, Tullayakorn; Matsuda, Naoki; Karbwang, Juntra; Viyanant, Vithoon; Hirayama, Kenji; Na-Bangchang, Kesara

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자료유형: 학술저널

저자정보: Plengsuriyakarn, Tullayakorn (Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine) Matsuda, Naoki (Division of Radiation Biology and Protection, Radioisotope Center) Karbwang, Juntra (Department of Clinical Product Development, Institute of Tropical Medicine [NEKKEN], Nagasaki University) Viyanant, Vithoon (Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine) Hirayama, Kenji (Department of Immunogenetics, Institute of Tropical Medicine [NEKKEN], Nagasaki University) Na-Bangchang, Kesara (Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제15호

발행연도: 2015.1

수록면: 6,279 - 6,284 (6page)

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Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is an important cancer in the Great Mekong region, particularly in Thailand. Limitations of treatment options and the lack of an effective diagnostic tool for early detection of CCA are major concerns for the control of this type of cancer. The aim of the study was to investigate anti-CCA activity of the ethanolic extract of Atractylodes lancea (Thunb.) DC., and the applicability of positron emission tomography-computed tomography (PET-CT) as a tool for detection and monitoring the progression of CCA in Opisthorchis viverrini (OV)/dimethylnitrosamine (DMN)-induced CCA hamsters. Male Syrian hamsters were used for toxicity tests and anti-CCA activity evaluation. Development of CCA was induced by initial feeding of 50 metacercariae of OV, followed by drinking water containing 12.5 ppm of DMN in hamsters. The ethanolic extract of A. lancea (Thunb.) DC. was administered orally for 30 days. PET-CT was performed every 4 weeks after initiation of CCA using 18F-fluorodeoxyglucose ($^{18}F-FDG$). Results from the present study suggest that the ethanolic extract of A. lancea (Thunb.) DC. rhizome exhibited promising anti-CCA activity and safety profile in the OV/DMN-induced hamster model. To successfully apply PET-CT as a tool for early detection of tumor development and progression, modification of radiolabeling approach is required to improve its specificity for CCA cells.

#Cholangiocarcinoma #anticancer #PET-CT #Atractylodes lancea #Thunb #) DC

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Plengsuriyakarn, Tullayakorn

소속기관 Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulab