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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Jae-Hun (Department of Biomedical Engineering, Hanyang University) Lee, Jong-Min (Department of Biomedical Engineering, Hanyang University) Kang, Eun-Joo (Department of Psychology, Kangwon National University) Kim, June-Sic (MEG Center, Departments of Neurosurgery, Seoul National University College of Medicine) Song, In-Chan (MEG Center, Radiology, Seoul National University College of Medicine) Chung, Chun-Kee (MEG Center, Departments of Neurosurgery, Seoul National University College of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제47권 제1호
발행연도
2010.1
수록면
17 - 25 (9page)

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Objective: The focus of this study is brain plasticity associated with semantic aspects of language function in patients with medial temporal lobe epilepsy (mTLE) Methods: Using longitudinal functional magnetic resonance imaging (fMRI), patterns of brain activation were observed in twelve left and seven right unilateral mTLE patients during a word-generation task relative to a pseudo-word reading task before and after anterior temporal section surgery. Results: No differences were observed in precentral activations in patients relative to normal controls (n = 12), and surgery did not alter the phonological-associated activations. The two mTLE patient groups showed left inferior prefrontal activations associated with semantic processing (word-generation>pseudo-word reading), as did control subjects. The amount of semantic-associated activation in the left inferior prefrontal region was negatively correlated with epilepsy duration in both patient groups. Following temporal resection, semantic-specific activations in inferior prefrontal region became more bilateral in left mTLE patients, but more left-lateralized in right mTLE patients. The longer the duration of epilepsy in the patients, the larger the increase in the left inferior prefrontal semantic-associated activation after surgery in both patient groups. Semantic activation of the intact hippocampus, which had been negatively correlated with seizure frequency, normalized after the epileptic side was removed. Conclusion: These results indicate alternation of semantic language network related to recruitment of left inferior prefrontal cortex and functional recovery of the hippocampus contralateral to the epileptogenic side, suggesting an intra- and inter-hemispheric reorganization following surgery.

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