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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 73 - 80 (8page)
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초록· 키워드
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Background and PurposezzThere is recent evidence of various types of morphological changes in the hippocampus of a rodent model of medial temporal lobe epilepsy (mTLE). However,little is known about such changes in humans. We examined the histological changes [i.e., neuronal loss, cell genesis, and granule cell dispersion (GCD)] in surgical hippocampal specimens taken from patients with mTLE.
MethodszzNissl staining, and nestin and Prox1 immunohistochemistry were performed on human hippocampal specimens obtained from patients with medically intractable mTLE, thus allowing the analysis of neuronal loss, cell genesis, and GCD, respectively. We also assessed the correlations between clinical parameters and the histopathologic findings.
ResultszzThe degree of cell genesis in the granule cell layer was significantly correlated with the severity of GCD, history of childhood febrile seizures, and frequent generalized seizures. Cell genesis was not correlated with cell death, age at seizure onset, duration of epilepsy, or the mean frequency of all seizures.
ConclusionszzOur results indicate that cell genesis in the dentate gyrus of patients with mTLE is associated with GCD and is influenced by the presence of febrile seizures during childhood and the frequency of episodes of generalized seizures.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Babb TL / 1984 / Temporal lobe volumetric cell densities in temporal lobe epilepsy / Epilepsia 25 : 729 ~ 740
Babb TL / 1987 / Pathological findings in epilepsy / Raven Press : 511 ~ 540
Bagri A / 2002 / The chemokine SDF1 regulates migration
Blumcke I / 2002 / Ammon’s horn sclerosis:a maldevelopmental disorder associated with temporal lobe epilepsy / Brain Pathol 12 : 199 ~ 211
Cavanagh JB / 1956 / Aetiological aspects of Ammon’s horn sclerosis associated with temporal lobe epilepsy / Br Med J 2 : 1403 ~ 1407
Babb TL / 1987 / Pathological findings in epilepsy / Raven Press : 511 ~ 540
Bagri A / 2002 / The chemokine SDF1 regulates migration
Blumcke I / 2002 / Ammon’s horn sclerosis:a maldevelopmental disorder associated with temporal lobe epilepsy / Brain Pathol 12 : 199 ~ 211
Cavanagh JB / 1956 / Aetiological aspects of Ammon’s horn sclerosis associated with temporal lobe epilepsy / Br Med J 2 : 1403 ~ 1407
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