지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제1호
- 발행연도
- 2019.1
- 수록면
- 54 - 63 (10page)
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초록· 키워드
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Objective: The neural correlates underlying the effects of emotional distraction during working memory (WM) tasks in patients with schizophrenia have yet to be clearly identified. Thus, the present study employed functional magnetic resonance imaging (fMRI) to investigate the effects of emotional distraction involving fear during WM maintenance in patients with schizophrenia. Methods: This study included 17 patients with schizophrenia who were diagnosed based on Diagnostic and Statistical Manual of Mental Disorders fourth edition, text revision (DSM-IV-TR) criteria and 17 matched healthy controls. Event-related fMRI data were acquired while the participants performed a delayed-response WM task that included neutral and fearful distractors. Results: Patients with schizophrenia may have tried to maintain WM function during the presentation of task-irrelevant fearful distractors that induced interruption and required attention. Compared to healthy controls, the schizophrenia patients exhibited significantly increased activity in the dorsolateral prefrontal cortex, medial prefrontal cortex, superior temporal gyrus, middle temporal gyrus, insula, hippocampus, caudate nucleus, and postcentral gyrus in a delayed-response WM task when presented with fearful relative to neutral distractors. In addition to its series of increased brain activations, prefrontal areas exhibited interconnections with more caudal brain regions, including temporal areas and the hippocampus and insula. Conclusion: The present study identified specific brain areas associated with the interaction between emotional regulation and cognitive functioning during fearful distractors presented while patients with schizophrenia performed a WM maintenance task. These findings further the current understanding of the neural correlates underlying the effects of emotional distraction on cognitive functioning in patients with schizophrenia.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Nuechterlein KH / 2004 / Identification of separable cognitive factors in schizophrenia / Schizophr Res 72:29~39
Adarsh Tripathi / 2018 / Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies / Clinical Psychopharmacology and Neuroscience 16(1):7~17
우영섭 / 2016 / Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients / Clinical Psychopharmacology and Neuroscience 14(1):1~16
Baddeley AD / 1986 / Working memory / Oxford University Press
Dolcos F / 2007 / Regional brain differences in the effect of distraction during the delay interval of a working memory task / Brain Res 1152:171~181
Adarsh Tripathi / 2018 / Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies / Clinical Psychopharmacology and Neuroscience 16(1):7~17
우영섭 / 2016 / Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients / Clinical Psychopharmacology and Neuroscience 14(1):1~16
Baddeley AD / 1986 / Working memory / Oxford University Press
Dolcos F / 2007 / Regional brain differences in the effect of distraction during the delay interval of a working memory task / Brain Res 1152:171~181
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