지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 321 - 328 (8page)
이용수
초록· 키워드
오류제보하기
Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the growth of hormone-dependent tumors, such as those of breast or prostate cancer. However, the molecular function of STS in tumor growth is still not clear. To elucidate the role of STS in cancer cell proliferation, we investigated whether STS is able to regulate the integrin signaling pathway. We found that overexpression of STS in HeLa cells increases the protein and mRNA levels of integrin ${\beta}1$ and fibronectin, a ligand of integrin ${\alpha}5{\beta}1$. Dehydroepiandrosterone (DHEA), one of the main metabolites of STS, also increases mRNA and protein expression of integrin ${\beta}1$ and fibronectin. Further, STS expression and DHEA treatment enhanced phosphorylation of focal adhesion kinase (FAK) at the Tyr 925 residue. Moreover, increased phosphorylation of ERK at Thr 202 and Tyr 204 residues by STS indicates that STS activates the MAPK/ERK pathway. In conclusion, these results suggest that STS expression and DHEA treatment may enhance MAPK/ERK signaling through up-regulation of integrin ${\beta}1$ and activation of FAK.
목차
등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
Abulafia, O. / 2009 / Sulfatase activity in normal and neoplastic endometrium / Gynecol. Obstet. Invest 67:57~60
Hye-Na Ahn / 2014 / Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus / Biomolecules & Therapeutics 22(4):347~354
Baglietto, L. / 2010 / Circulating steroid hormone levels and risk of breast cancer for postmenopausal women / Cancer Epidemiol. Biomarkers Prev 19:492~502
Cai, C. / 2011 / Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors / Cancer Res 71:6503~6513
Cheung, P. F. / 2008 / FAK-mediated activation of ERK for eosinophil migration: a novel mechanism for infection-induced allergic inflammation / Int. Immunol 20:353~363
Hye-Na Ahn / 2014 / Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus / Biomolecules & Therapeutics 22(4):347~354
Baglietto, L. / 2010 / Circulating steroid hormone levels and risk of breast cancer for postmenopausal women / Cancer Epidemiol. Biomarkers Prev 19:492~502
Cai, C. / 2011 / Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors / Cancer Res 71:6503~6513
Cheung, P. F. / 2008 / FAK-mediated activation of ERK for eosinophil migration: a novel mechanism for infection-induced allergic inflammation / Int. Immunol 20:353~363
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Overexpressions of Vimentin and Integrins in Human Metastatic Spine Tumors
대한신경외과학회지
2015 .01
-
Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Spatio-temporal Analysis of Integrin Tension during Cancer Metastasis
대한외과학회 학술대회 초록집
2020 .11
-
G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer
Yonsei Medical Journal
2016 .01
-
일개 대학병원 간호사에서 직무스트레스와 혈청 dehydroepiandrosterone sulfate (DHEAS)의 관계
대한직업환경의학회 학술대회 논문집
2017 .11
-
Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
Cancer Research and Treatment
2022 .07
-
The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women
대한골대사학회지
2017 .01
-
The association between serum dehydroepiandrosterone sulfate (DHEAS) levels and job-related stress among female nurses
대한직업환경의학회지
2019 .09
-
Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells
International Journal of Oral Biology
2020 .01
-
The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate
Annals of Dermatology
2018 .01
-
CD103+ Cells and Chemokine Receptor Expression in Breast Cancer
Immune Network
2023 .06
-
Loss of Rab25 promotes the development of skin tumor through the dysregulation of integrin trafficking
한국실험동물학회 학술발표대회 논문집
2018 .01
-
코티졸, Dehydroepiandrosterone Sulphate와 우울증상 심각도와의 상관성
생물치료정신의학
2016 .06
-
Bee Venom Exerts Neuroprotective Effects on Neuronal Cells and Astrocytes under Hypoxic Conditions Through MAPK Signaling Pathways
Neonatal medicine
2016 .01
-
Stable Expression of Bovine Integrin Beta-6 Increases Susceptibility of Goat Kidney Cell Line to Foot-and-mouth Disease Virus
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .03
-
미세파상 패턴 ECM 에서 세포질 FAK 신호의 실시간 FRET 이미징
의공학회지
2019 .01
-
Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma
Annals of Coloproctology
2015 .01
-
사람 호흡기 상피세포에서 MUC5B 발현에 대한 Polyinosinic-Polycytidylic Acid의 효과
대한이비인후-두경부외과학회지
2015 .01
-
Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
Childhood Kidney Diseases
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0