지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 93 - 100 (8page)
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초록· 키워드
오류제보하기
Objectives：Cortisol and dehydroepiandrosterone sulfate(DHEAS) are neuroactive steroids related mood disorder as well as stress response. The purposes of this study are to examine the correlations between cortisol, DHEAS and severity of depressive symptoms and to evaluate the possibility of cortisol and DHEAS as biomarkers for depression.
Methods：A total of 60 participants who had no history of psychiatric disease were recruited. We assessed the severity of depressive symptoms using the Beck Depression Inventory(BDI) and the Hamilton Depression Rating Scale(HAMD). The blood samples were collected between 12 PM to 14 PM. We applied an ELISA to measure the level of cortisol and DHEAS.
Results：The depressive group showed higher cortisol level(Base on BDI : 13.64±7.91 ug/dL, p＜0.001 ; Base on HAMD: 14.14±8.34 ug/dL, p＜0.001). Cortisol level showed positive correlation with the severity of depressive symptoms based on BDI (r=0.572 ; p＜0.01) and HAMD(r=0.638 ; p＜0.01). DHEAS level significantly correlated with BDI score (r=0.398 ; p＜0.01) but not with HAMD score.
Conclusion：These findings suggest that cortisol and DHEAS may have a role as biomarkers for evaluating depression. DHEAS was associated with only one side of two scales. This may suggest the level of steroid hormone is different depending on specific depressive symptoms.
Methods：A total of 60 participants who had no history of psychiatric disease were recruited. We assessed the severity of depressive symptoms using the Beck Depression Inventory(BDI) and the Hamilton Depression Rating Scale(HAMD). The blood samples were collected between 12 PM to 14 PM. We applied an ELISA to measure the level of cortisol and DHEAS.
Results：The depressive group showed higher cortisol level(Base on BDI : 13.64±7.91 ug/dL, p＜0.001 ; Base on HAMD: 14.14±8.34 ug/dL, p＜0.001). Cortisol level showed positive correlation with the severity of depressive symptoms based on BDI (r=0.572 ; p＜0.01) and HAMD(r=0.638 ; p＜0.01). DHEAS level significantly correlated with BDI score (r=0.398 ; p＜0.01) but not with HAMD score.
Conclusion：These findings suggest that cortisol and DHEAS may have a role as biomarkers for evaluating depression. DHEAS was associated with only one side of two scales. This may suggest the level of steroid hormone is different depending on specific depressive symptoms.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (44)
참고문헌 신청
[학술지(정기간행물)] - Pariante CM / 2008 / The HPA axis in major depression: classical theories and new developments / Trends Neurosci 31 : 464 ~ 468
[학술지(정기간행물)] - Miller GE / 2007 / If it goes up, must it come down? Chronic stress and the hypothalamic-pituitaryadrenocortical axis in humans / Psychol Bull 133 : 25 ~ 45
[학술지(정기간행물)] - Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267 : 1244 ~ 1252
[학술지(정기간행물)] - Chrousos GP / 2009 / Stress and disorders of the stress system / Nat Rev Endocrinol 5 : 374 ~ 381
[학술지(정기간행물)] - Herbert J / 2006 / Do corticosteroids damage the brain? / J Neuroendocrinol 18 : 393 ~ 411
[학술지(정기간행물)] - Miller GE / 2007 / If it goes up, must it come down? Chronic stress and the hypothalamic-pituitaryadrenocortical axis in humans / Psychol Bull 133 : 25 ~ 45
[학술지(정기간행물)] - Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267 : 1244 ~ 1252
[학술지(정기간행물)] - Chrousos GP / 2009 / Stress and disorders of the stress system / Nat Rev Endocrinol 5 : 374 ~ 381
[학술지(정기간행물)] - Herbert J / 2006 / Do corticosteroids damage the brain? / J Neuroendocrinol 18 : 393 ~ 411
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UCI(KEPA) : I410-ECN-0101-2017-512-000861234