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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 493 - 501 (9page)
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The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson's disease, Alzheimer's disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.
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참고문헌 (99)
참고문헌 신청
Abud EM / 2017 / iPSC-derived human microglia-like cells to study neurological diseases / Neuron 94:278~293.e9
Alper J / 2009 / Geron gets green light for human trial of ES cell-derived product / Nat Biotechnol 27:213~214
Assawachananont J / 2014 / Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice / Stem Cell Reports 2:662~674
Bejleri D / 2018 / A bioprinted cardiac patch composed of cardiac-specific extracellular matrix and progenitor cells for heart repair / Adv Heathc Mater 7:e1800672
Charron D / 2009 / Immunogenicity and allogenicity:a challenge of stem cell therapy / J Cardiovasc Transl Res 2:130~138
Alper J / 2009 / Geron gets green light for human trial of ES cell-derived product / Nat Biotechnol 27:213~214
Assawachananont J / 2014 / Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice / Stem Cell Reports 2:662~674
Bejleri D / 2018 / A bioprinted cardiac patch composed of cardiac-specific extracellular matrix and progenitor cells for heart repair / Adv Heathc Mater 7:e1800672
Charron D / 2009 / Immunogenicity and allogenicity:a challenge of stem cell therapy / J Cardiovasc Transl Res 2:130~138
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Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta
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Application of stem cells in pulmonary toxicity research
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Current Status and Future Perspectives on Stem Cell-Based Therapies for Parkinson’s Disease
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Erythroid Differentiation of Induced Pluripotent Stem Cells Co-cultured with OP9 Cells for Diagnostic Purposes
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Highly efficient human hematopoietic stem and progenitor cell generation from induced pluripotent stem cells using a simple scalable monolayer culture system
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Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
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[S13-1] Modeling neurodevelopmental disorders using human pluripotent stem cells
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New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta
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Human pluripotent stem cell-derived 3D intestinal organoids and their applications
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