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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 57 - 61 (5page)
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Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Fisetin significantly relaxed fluoride-, thromboxane $A_2$- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, fisetin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of fisetin on agonist-induced vascular contraction regardless of endothelial function.
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참고문헌 (26)
참고문헌 신청
Ajay, M / 2003 / Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta / Life Sci 74:603~612
Ash, D / 2015 / Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells / Am. J. Cancer Res 5:481~497
Cheong, H / 1998 / Studies of structure activity relationship of flavonoids for the anti-allergic actions / Arch. Pharm. Res 21:478~480
Goyal, R / 2009 / Maturation and the role of PKC-mediated contractility in ovine cerebral arteries / Am. J. Physiol. Heart Circ. Physiol 297:H2242~2252
Gu, Z / 2007 / Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells / Exp. Cell Res 313:849~866
Ash, D / 2015 / Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells / Am. J. Cancer Res 5:481~497
Cheong, H / 1998 / Studies of structure activity relationship of flavonoids for the anti-allergic actions / Arch. Pharm. Res 21:478~480
Goyal, R / 2009 / Maturation and the role of PKC-mediated contractility in ovine cerebral arteries / Am. J. Physiol. Heart Circ. Physiol 297:H2242~2252
Gu, Z / 2007 / Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells / Exp. Cell Res 313:849~866
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