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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 437 - 445 (9page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.437
이용수
초록· 키워드
오류제보하기
α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic α-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Flack JM / 2003 / Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients / J Am Coll Cardiol 41:1148~1155
Ohanian J / 2001 / Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension / J Hum Hypertens 15:93~98
Touyz RM / 2001 / Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients / Hypertension 38:56~64
Staiculescu MC / 2013 / Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodelling / Cardiovasc Res 98:428~436
Horowitz A / 1996 / Mechanisms of smooth muscle contraction / Physiol Rev 76:967~1003
Ohanian J / 2001 / Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension / J Hum Hypertens 15:93~98
Touyz RM / 2001 / Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients / Hypertension 38:56~64
Staiculescu MC / 2013 / Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodelling / Cardiovasc Res 98:428~436
Horowitz A / 1996 / Mechanisms of smooth muscle contraction / Physiol Rev 76:967~1003
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