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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제1호
- 발행연도
- 2016.1
- 수록면
- 69 - 74 (6page)
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초록· 키워드
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The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Cardamonin significantly relaxed fluoride-, phenylephrine-, and phorbol ester-induced vascular contractions, suggesting that it has an anti-hypertensive effect on agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, cardamonin significantly inhibited the fluoride-induced increase in pMYPT1 level and phenylephrine-induced increase in pERK1/2 level, suggesting inhibition of Rhokinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. This study provides evidence that the relaxing effect of cardamonin on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rhokinase and MEK activity.
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참고문헌 (21)
참고문헌 신청
Luís Moreira Gonçalves / 2014 / An Overview on Cardamonin / Journal of Medicinal Food 17(6):633~640
Chow YL / 2012 / Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway / Int Immunopharmacol 12:657~665
Somlyo AP / 1994 / Signal transduction and regulation in smooth muscle / Nature 372:231~236
Somlyo AP / 1998 / From pharmacomechanical coupling to G-proteins and myosin phosphatase / Acta Physiol Scand 164:437~448
Uehata M / 1997 / Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension / Nature 389:990~994
Chow YL / 2012 / Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway / Int Immunopharmacol 12:657~665
Somlyo AP / 1994 / Signal transduction and regulation in smooth muscle / Nature 372:231~236
Somlyo AP / 1998 / From pharmacomechanical coupling to G-proteins and myosin phosphatase / Acta Physiol Scand 164:437~448
Uehata M / 1997 / Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension / Nature 389:990~994
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