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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 182 - 190 (9page)
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초록· 키워드
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The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied, using generation 1, 4 and 7 dendrimer (G1, G4 and G7, respectively). As a marker molecule for the direction and magnitude of EOF, a neutral molecule, acetoaminophen (AAP) was used. The visualization of dendrimer permeation into the current conducting pore (CCP) of skin was made using G4-fluorescein isothiocyanate (FITC) conjugate and confocal microscopy. Without dendrimer, anodal flux of AAP was much higher than cathodal or passive flux. When G1 dendrimer was added, anodal flux decreased, presumably due to the decrease in EOF by the association of G1 dendrimer with net negative charge in CCP. As the generation increased, larger decrease in anodal flux was observed, and the direction of EOF was reversed. Small amount of methanol used for the preparation of dendrimer solution also contributed to the decrease in anodal flux of AAP. Cross-sectional view perpendicular to the skin surface by confocal laser scanning microscope (CLSM) study showed that G4 dendrimer-FITC conjugate (G4-FITC) can penetrate into the viable epidermis and dermis under anodal current. The permeation route seemed to be localized on hair follicle region. These results suggest that PAMAM dendrimers can permeate into CCP and change the magnitude and direction of EOF. Overall, we obtained a better understanding on the mechanistic insights into the electroosmosis phenomena and its role on flux during iontophoresis.
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참고문헌 (34)
참고문헌 신청
Abla, N. / 2005 / Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis / Pharm. Res. 22:2069~2078
Bronaugh, R. L. / 1982 / Methods for in vitro percutaneous absorption studies. II. Animal models for human skin / Toxicol. Appl. Pharmacol. 62:481~488
Burnette, R. R. / 1987 / Characterization of the permselective properties of excised human skin during iontophoresis / J. Pharm. Sci. 76:765~773
Chauhan, A. S. / 2003 / Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin / J. Control. Release 90:335~343
Choudhary, S. / 2017 / Impact of dendrimers on solubility of hydrophobic drug molecules / Front. Pharmacol. 8:261
Bronaugh, R. L. / 1982 / Methods for in vitro percutaneous absorption studies. II. Animal models for human skin / Toxicol. Appl. Pharmacol. 62:481~488
Burnette, R. R. / 1987 / Characterization of the permselective properties of excised human skin during iontophoresis / J. Pharm. Sci. 76:765~773
Chauhan, A. S. / 2003 / Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin / J. Control. Release 90:335~343
Choudhary, S. / 2017 / Impact of dendrimers on solubility of hydrophobic drug molecules / Front. Pharmacol. 8:261
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