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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose To investigate whether transcranial direct-current stimulation (tDCS) can improve cognition in stroke patients.
Methods Forty-five stroke patients (20 males and 25 females, average age: 62.7 years) with cognitive dysfunction were included in this prospective, double-blinded, randomized case–control study. All patients were right-handed and the mean elapsed time after stroke was 39.3 days. Three different treatments groups were used: (1) anodal stimulation of the left anterior temporal lobe, (2) anodal stimulation of the right anterior temporal lobe, and (3) sham stimulation. tDCS was delivered for 30 minutes at 2 mA with 25 cm2 electrodes, five times/week, for a total of 3 weeks, using a Phoresor II Auto Model PM 850 (IOMED®). The evaluation of cognitive impairment was based on a Computerized Neuropsychological Test (CNT), Korean Mini-Mental State Examination (K-MMSE). The Korean version of the Modified Barthel Index (K-MBI) was used to assess activities of daily living functionality. These evaluations were conducted in all patients before and after treatment.
Results Each group included 15 patients. Pre-treatment evaluation showed no significant differences between the three groups for any of the parameters. There was significant improvement in the verbal learning test on the CNT in the left anodal stimulation group (P<0.05). There were, however, no significant differences in the K-MMSE or K-MBI scores among the three groups.
Conclusions These results demonstrated the beneficial effects of anodal tDCS on memory function. Thus, tDCS can successfully be used as a treatment modality for patients with cognitive dysfunction after stroke.
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참고문헌 (19)
참고문헌 신청
Boggio PS / 2007 / Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients / Restor Neurol Neurosci 25 : 123 ~
Boggio PS / 2009 / Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease / J Neurol Neurosurg Psychiatry 8
Boggio PS / 2009 / Temporal lobe cortical electrical stimulation during the encoding and retrieval phase reduces false memories / PLoS One 4 : e4959 ~
Chen R. / 2004 / Interactions between inhibitory and excitatory circuits in the human motor cortex / Exp Brain Res 154 : 1 ~ 10
Chi RP / 2010 / Visual memory improved by non-invasive brain stimulation / Brain Res 1353 : 168 ~ 175
Boggio PS / 2009 / Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease / J Neurol Neurosurg Psychiatry 8
Boggio PS / 2009 / Temporal lobe cortical electrical stimulation during the encoding and retrieval phase reduces false memories / PLoS One 4 : e4959 ~
Chen R. / 2004 / Interactions between inhibitory and excitatory circuits in the human motor cortex / Exp Brain Res 154 : 1 ~ 10
Chi RP / 2010 / Visual memory improved by non-invasive brain stimulation / Brain Res 1353 : 168 ~ 175
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