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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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초록· 키워드
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Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed “glycemic memory.” In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the “sweetened” environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to “breaking” the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action.
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참고문헌 (59)
참고문헌 신청
Mozaffarian D / 2015 / Heart disease and stroke statistics:2015 update: a report from the American Heart Association / Circulation 131:e29~322
Wang Y / 2015 / Prediction of heart failure in patients with type 2 diabetes mellitus: a systematic review and meta-analysis / Diabetes Res Clin Pract 108:55~66
Lind M / 2011 / Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study / Lancet 378:140~146
Wende AR / 2012 / Mechanisms of lipotoxicity in the cardiovascular system / Curr Hypertens Rep 14:517~531
Schilling JD / 2012 / Diabetic cardiomyopathy: bench to bedside / Heart Fail Clin 8:619~631
Wang Y / 2015 / Prediction of heart failure in patients with type 2 diabetes mellitus: a systematic review and meta-analysis / Diabetes Res Clin Pract 108:55~66
Lind M / 2011 / Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study / Lancet 378:140~146
Wende AR / 2012 / Mechanisms of lipotoxicity in the cardiovascular system / Curr Hypertens Rep 14:517~531
Schilling JD / 2012 / Diabetic cardiomyopathy: bench to bedside / Heart Fail Clin 8:619~631
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