지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제1호
- 발행연도
- 2021.1
- 수록면
- 51 - 58 (8page)
이용수
초록· 키워드
오류제보하기
Oxidative stress-induced neurodegeneration is one of several etiologies underlying neurodegenerative disease. In the present study, we investigated the functional role of histone methyltransferase G9a in oxidative stress-induced degeneration in human SH-SY5Y neuroblastoma cells. Cell viability significantly decreased on H2O2 treatment; however, treatment with the G9a inhibitor BIX01294 partially attenuated this effect. The expression of neuron-specific genes also decreased in H2O2- treated cells; however, it recovered on G9a inhibition. H2O2-treated cells showed high levels of H3K9me2 (histone H3 demethylated at the lysine 9 residue), which is produced by G9a activation; BIX01294 treatment reduced aberrant activation of G9a. H3K9me2 occupancy of the RE-1 site in neuron-specific genes was significantly increased in H2O2-treated cells, whereas it was decreased in BIX01294-treated cells. The differentiation of H2O2-treated cells also recovered on G9a inhibition by BIX01294. Consistent results were observed when used another G9a inhibitor UCN0321. These results demonstrate that oxidative stress induces aberrant activation of G9a, which disturbs the expression of neuron-specific genes and progressively mediates neuronal cell death. Moreover, a G9a inhibitor can lessen aberrant G9a activity and prevent neuronal damage. G9a inhibition may therefore contribute to the prevention of oxidative stress-induced neurodegeneration.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Kauser H / 2016 / Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia / Brain Res 1636:152~160
Pradhan SS / 2017 / Anti-inflammatory and neuroprotective effects of PGE2 EP4 signaling in models of Parkinson's disease / J Neuroimmune Pharmacol 12:292~304
Neniskyte U / 2016 / Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase / Int J Biochem Cell Biol 81(Pt B):346~355
Olney JW / 2002 / Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain / Brain Res Dev Brain Res 133:115~126
Wang X / 2016 / Nicotinamide mononucleotide protects against -amyloid oligomer-induced cognitive impairment and neuronal death / Brain Res 1643:1~9
Pradhan SS / 2017 / Anti-inflammatory and neuroprotective effects of PGE2 EP4 signaling in models of Parkinson's disease / J Neuroimmune Pharmacol 12:292~304
Neniskyte U / 2016 / Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase / Int J Biochem Cell Biol 81(Pt B):346~355
Olney JW / 2002 / Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain / Brain Res Dev Brain Res 133:115~126
Wang X / 2016 / Nicotinamide mononucleotide protects against -amyloid oligomer-induced cognitive impairment and neuronal death / Brain Res 1643:1~9
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis
Journal of Veterinary Science
2017 .12
-
Pectinase-treated Panax ginseng ameliorates hydrogen peroxide-induced oxidative stress in GC-2 sperm cells and modulates testicular gene expression in aged rats
Journal of Ginseng Research
2016 .04
-
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Kidney Research and Clinical Practice
2021 .01
-
Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derived neurotrophic factor upregulation
Journal of Ginseng Research
2020 .07
-
인체 신경세포에서 청뇌명신환(淸腦明神丸)의 산화적 스트레스에 대한 세포보호 효과
대한한의학방제학회지
2017 .01
-
7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Structural modifications of the prostate in hypoxia, oxidative stress, and chronic ischemia
Investigative and Clinical Urology
2015 .01
-
Neuroprotective effects of mulberry fruit on H2O2-induced oxidative neuronal damage via MAPK/NF-κB signaling pathway in SH-SY5Y neuroblastoma cells
한국실험동물학회 학술발표대회 논문집
2020 .07
-
The Neuro-Protective Effect of the Methanolic Extract of Perilla frutescens var. japonica and Rosmarinic Acid against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress in C6 Glial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
Natural Product Sciences
2018 .09
-
Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Therapeutic Potential of Methanol Extract of Euonymus alatus in HT22 Cells Through Neuroprotective Mechanisms
Natural Product Sciences
2025 .03
-
Protective effects of remifentanil against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in human osteoblasts
Journal of dental anesthesia and pain medicine
2016 .01
-
Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells
Journal of Pharmacopuncture
2022 .09
-
Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
Korean Journal of Ophthalmology
2015 .01
-
Celecoxib의 항산화 작용에 따른 성체 치주인대 줄기세포 사멸억제
대한통합의학회지
2023 .05
-
Protective effect of the aerial parts of Silybum marianum against amyloid β protein (25-35)-induced neuronal death in cultured neurons
Journal of Biomedical and Translational Research
2016 .12
-
Stem Cell Therapy for Neurodegenerative Diseases
Hanyang Medical Reviews
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0