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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 61 - 68 (8page)
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초록· 키워드
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In order to develop an improved paclitaxel formulation vehicle, a micelle forming solubilizer, Aceporol 330 was synthesized. It was previously reported that Aceporol 330 provided the linearity of paclitaxel plasma pharmacokinetics. In this study, the single dose toxicity test and 2-week repeated dose toxicity test of Aceporol 330 was performed in beagle dogs after intravenous administration. Single dose and 2-week repeated dose toxicity test of Aceporol 330 showed fever/generalized erythema, severe vomiting, and diarrhea in beagle dogs. However, those toxicities were less severe than those of Cremophor EL. Blood chemistry analysis of 2-week repeatedly treated beagle dogs with Aceporol 330 showed significant elevation of total cholesterol (TCHO) and triglyceride (TG) compared to that of control group. Cremophor EL also significantly increased total cholesterol (TCHO) and triglyceride (TG) as much as Aceporol 330. Results from this study indicated that Aceporol 330 was less toxic than Cremophor EL. Based on the pharmacokinetic advantages and the low toxicity of Aceporol 330 in single dose and 2-week repeated dose toxicity test, Aceporol 330 has a potential for use as a safer solubilizer for paclitaxel than Cremophor EL.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Cai S / 2007 / Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery / Pharm. Res 24(11):2099~2109
Gelderblom H / 2001 / Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation / Eur. J. Cancer 37(13):1590~1598
Eun Ju Jeong / 2007 / Hematological and Blood Biochemical Values of Laboratory Beagle Dogs / Laboratory Animal Research 23(3):223~229
Kang B. K / 2004 / Controlled release of paclitaxel from microemulsion containing PLGA and evaluation of anti-tumor activity in vitro and in vivo / Int. J. Pharm 286(1-2):147~156
Konno T / 2003 / Enhanced solubility of paclitaxel using water-soluble and biocompatible 2-methacryloyloxyethyl phosphorylcholine polymers / Biomed. Mater. Res 65(2):209~214
Gelderblom H / 2001 / Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation / Eur. J. Cancer 37(13):1590~1598
Eun Ju Jeong / 2007 / Hematological and Blood Biochemical Values of Laboratory Beagle Dogs / Laboratory Animal Research 23(3):223~229
Kang B. K / 2004 / Controlled release of paclitaxel from microemulsion containing PLGA and evaluation of anti-tumor activity in vitro and in vivo / Int. J. Pharm 286(1-2):147~156
Konno T / 2003 / Enhanced solubility of paclitaxel using water-soluble and biocompatible 2-methacryloyloxyethyl phosphorylcholine polymers / Biomed. Mater. Res 65(2):209~214
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