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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 265 - 270 (6page)
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This study was conducted to compare the difference of quantitative toxicity of a compound which has different metabolic pathways in minipig and beagle dog. Coumarin which has low toxic values in human and different metabolic pathways in these two animals was chosen as a test compound. In the single dose toxicity study conducted using minipig, maximum tolerable dose (MTD) of coumarin was determined to be 200 ㎎/㎏/day and liver was confirmed as a target organ. However, MTD value of coumarin in the dog study was 60-100 ㎎/㎏/day and target organs were liver and kidneys. Minipig which has similar metabolic pathway of coumarin with human showed similar acute toxicity when compared with previously published data. Although it is difficult to conclude without further toxicity studies, it was expected from this study that animals having similar metabolic pathways with human should be chosen during the toxicity studies of new chemicals to predict the accurate toxicity and target organs in the human.
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감사의 글
참고문헌
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Anzenbacher, P / 1998 / Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples 26 : 56 ~ 59
2. [학술지(정기간행물)] - Balls / 1994193-211. / Replacement of animal procedures
3. [학술지(정기간행물)] - Bollen, P / 1997 / The Gottingen minipig in pharmacology and toxicology 80 : 3 ~ 4
4. [학술지(정기간행물)] - Bollen, P / 2000 / Important biological features. In The laboratory swine 1st ed : 1 ~ 15
5. [학술지(정기간행물)] - / 2006 / Ellegaard Newsletter 25
2. [학술지(정기간행물)] - Balls / 1994193-211. / Replacement of animal procedures
3. [학술지(정기간행물)] - Bollen, P / 1997 / The Gottingen minipig in pharmacology and toxicology 80 : 3 ~ 4
4. [학술지(정기간행물)] - Bollen, P / 2000 / Important biological features. In The laboratory swine 1st ed : 1 ~ 15
5. [학술지(정기간행물)] - / 2006 / Ellegaard Newsletter 25
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UCI(KEPA) : I410-ECN-0101-2009-510-016364216