An Efficient Method for the Large-Scale Synthesis of Atorvastatin Calcium

Lee, Hong-Woo; Kim, Young-Min; Yoo, Choong-Leol; Kang, Sung-Kwon; Ahn, Soon-Kil

추천

검색

자료유형: 학술저널

저자정보: Lee, Hong-Woo (Chemical Process Research and Development Laboratory, Chemical Research Group, Chong Kun Dang Research Institute) Kim, Young-Min (Chemical Process Research and Development Laboratory, Chemical Research Group, Chong Kun Dang Research Institute) Yoo, Choong-Leol (Chemical Process Research and Development Laboratory, Chemical Research Group, Chong Kun Dang Research Institute) Kang, Sung-Kwon (Chemical Process Research and Development Laboratory, Chemical Research Group, Chong Kun Dang Research Institute) Ahn, Soon-Kil (Chemical Process Research and Development Laboratory, Chemical Research Group, Chong Kun Dang Research Institute)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제16권 제1호

발행연도: 2008.1

수록면: 28 - 33 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Efficient hydrolysis of boronate compound 9 aimed at the viable synthesis for commercial production and purification of Atorvastatin calcium is reported. Detail studies of evaluation procedure are also reported.

#Atorvastatin #Large-scale synthesis #3-hydroxy-3-methylglutaryl-coenzyme A #HMG-CoA) reductase inhibitor #Hydrolysis

참고문헌 (17)

참고문헌 신청

Baumann, K. L / 1992 / The convergent synthesis of CI-981, an optically active, highly potent, tissue selective inhibitor of HMG-CoA reductase / Tetrahedron Lett 33:2283~2284

Brazil,M / 2002 / A new use for statins / Nature Reviews Drug Discovery 1:934

Brower, P. L / 1992 / The synthesis of (4R-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl- 1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase / Tetrahedron Lett 33:2279~2282

Butler, D. E / 1989 / ). Improved process for trans-6-[2-(substituted- pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. W.O. Patent 89/07598

Butler, D. E / 2002 / Novel Process for the synthesis of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydropyran- 2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole- 3-carboxylic acid phenylamide. W.O. Patent 02/055519

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!