지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: Atorvastatin, a HMG-CoA reductase inhibitor is widely prescribed in hyperlipidemic patients and telmisartan,an angiotensin receptor blocker is frequently used in the treatment of hypertension. Both drugs are substrates of organicanion transporting polypeptide (OATP) expressed in basolateral membrane in the liver, and undergo high first passmetabolism. Therefore, OATP-mediated hepatic uptake is important for disposition and metabolism of these drugs. Thepresent study was designed to investigate the pharmacokinetic interactions between atorvastatin and telmisartan in rats. Method: Young adult SD rats were divided into three groups (n=6, each) and atorvastatin (10 mg/kg) and telmisartan(4 mg/kg) were orally given alone and together. Heparinized blood was serially taken and plasma concentrations of bothdrugs were measured using HPLC-MS/MS. Pharmacokinetic parameters of two drugs were calculated. Results: No significantpharmacokinetic change was found except a delay of time to peak of telmisartan when administered with atorvastatin. Each drug at the present dosage seemed to be insufficient to alter the pharmacokinetic parameters of itscounterpart drug. Conclusion: Conclusively, co-administration of atorvastatin and telmisartan may lead to negligibleclinical consequences.
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참고문헌 (21)
참고문헌 신청
Backman JT / 2005 / Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites / Clin Pharmacol Ther 78 : 154 ~ 167
DeGorter MK / 2012 / Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity / Mol Pharm 9 : 986 ~ 995
Grube M / 2006 / Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart / Clin Pharmacol Ther 80 : 607
Hermann M / 2004 / Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients / Clin Pharmacol Ther 76 : 388 ~ 391
Herv F / 1944 / Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding / Clin Pharmacokinet 26 : 44 ~ 58
DeGorter MK / 2012 / Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity / Mol Pharm 9 : 986 ~ 995
Grube M / 2006 / Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart / Clin Pharmacol Ther 80 : 607
Hermann M / 2004 / Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients / Clin Pharmacol Ther 76 : 388 ~ 391
Herv F / 1944 / Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding / Clin Pharmacokinet 26 : 44 ~ 58
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