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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제6호
- 발행연도
- 2004.1
- 수록면
- 401 - 407 (7page)
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초록· 키워드
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Background : The statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are approved for cholesterol reduction, and may also be beneficial in the treatment of inflammatory disease. In this study, atorvastatin was tested in experimental colitis, a disease model of inflammatory bowel disease. Methods : To induce colitis, dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS) were administrated to C57BL/6 or BALB/c mice. Mice were monitored daily for loss of body weight and survival for indicated days. Colon length and histology were examined after sacrifice. Results : The administration of DSS induced marked colonic inflammation and shortening, and resulted in a loss of body weight. DSS-induced colitis was not affected by atorvastatin treatment, but in contrast, the administration of atorvastatin relieved TNBS-induced colitis with a resultant rapid recovery of weight loss and a reduction in colonic length shortening. Histologically, inflammatory cell infiltration in the colonic wall, mucosal ulceration and crypt disruption were also suppressed in atorvastatin treated mice. Conclusions : These results suggest that atorvastatin preserves intestinal integrity in colitis, probably via the modulation of Th cell-mediated immune response, in a manner independent of innate immunity.
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참고문헌 (21)
참고문헌 신청
/ 1995 / Antibodies tointerleukin 12 abrogate established experimental colitis in mice, 182 : 1281 ~ 1290
/ 1996 / Hapten-induced modelof murine inflammatory bowel disease: mucosa immune responsesand protection by tolerance. 157 : 2174 ~ 2185
/ 1997 / Lovastatin and phenylacetateinhibit the induction of nitric oxide synthase and cytokinesin rat primary astrocytes, microglia, and macrophages 100 : 2671 ~ 2679
/ 1998 / Effects of lowering averageof below-average cholesterol levels on the progression of carotidatherosclerosis results of the LIPID Atherosclerosis Substudy. 97 : 1784
/ 1998 / Effects of statins on triglyceride metabolism. 81 : 32 ~ 35
/ 1996 / Hapten-induced modelof murine inflammatory bowel disease: mucosa immune responsesand protection by tolerance. 157 : 2174 ~ 2185
/ 1997 / Lovastatin and phenylacetateinhibit the induction of nitric oxide synthase and cytokinesin rat primary astrocytes, microglia, and macrophages 100 : 2671 ~ 2679
/ 1998 / Effects of lowering averageof below-average cholesterol levels on the progression of carotidatherosclerosis results of the LIPID Atherosclerosis Substudy. 97 : 1784
/ 1998 / Effects of statins on triglyceride metabolism. 81 : 32 ~ 35
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