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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 43 - 46 (4page)
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초록· 키워드
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The immunosuppressive properties of flavonoids were examined for the first time by testing their effects on T-cell-mediated antibody production, using a classical plague-forming cell (PFC) assay in mice. Among the tested flavonoids including naringenin, chrysin, flavonol, galangin, quercetin, morin, myricetin and biochanin A, only quercetin, orally administered at 25 mg/kg, significantly inhibited the number of IgMproducing PFCs induced by sheep red blood cells (SRBC). Interestingly, biochanin A (isoflavone) increased the number of PFCs, suggesting an immunostimulatory effect. The other flavonoids tested did not inhibit or enhance PFC response significantly. Quercetin was also found to show thymus atrophy dose-dependently at 5-500 mg/kg. All these results indicate that quercetin inhibits in vivo antibody production probably by inhibiting T-cell function.
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참고문헌 (12)
참고문헌 신청
Bullock, R. W. / 1972 / Spontaneous B cell activation due to loss of normal mouse serum suppressor / Eur. J. Immunol 2:514~517
Hirano, T. / 1989 / Effects of synthetic and naturally-occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes / Life Sci 45:1407~1411
Kim, C. J. / 1990 / Pharmacological activities of flavonoids (I) Relationships of chemical structures of flavonoids and their inhibitory activity of hypersensitivity / Yakhak Hoiji 34:348~364
Kim, H. P. / 2004 / Anti-inflammatory plant flavonoids and cellular action mechanisms / J. Pharmacol. Sci 96:229~245
Kimata, M. / 2000 / Effects of luteolin and other flavonoids on IgE-mediated allergic reactions / Planta Med 66:25~29
Hirano, T. / 1989 / Effects of synthetic and naturally-occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes / Life Sci 45:1407~1411
Kim, C. J. / 1990 / Pharmacological activities of flavonoids (I) Relationships of chemical structures of flavonoids and their inhibitory activity of hypersensitivity / Yakhak Hoiji 34:348~364
Kim, H. P. / 2004 / Anti-inflammatory plant flavonoids and cellular action mechanisms / J. Pharmacol. Sci 96:229~245
Kimata, M. / 2000 / Effects of luteolin and other flavonoids on IgE-mediated allergic reactions / Planta Med 66:25~29
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