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자료유형
학술저널
저자정보
Park, Jong-Lyul (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology) Kim, Seon-Kyu (Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Kim, Jeong-Hwan (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology) Yun, Seok Joong (Department of Urology, Chungbuk National University College of Medicine) Kim, Wun-Jae (Department of Urology, Chungbuk National University College of Medicine) Kim, Won Tae (Department of Urology, Chungbuk National University College of Medicine) Jeong, Pildu (Department of Urology, Chungbuk National University College of Medicine) Kang, Ho Won (Department of Urology, Chungbuk National University Hospital) Kim, Seon-Young (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology)
저널정보
한국유전체학회 Genomics & informatics Genomics & informatics 제16권 제3호
발행연도
2018.1
수록면
71 - 74 (4page)

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Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

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