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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Joo-Heon (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Lee, Young-Jeon (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University) Lee, Sang-Un (Department of Physical Therapy, Aomori University of Health and Welfare) Suzuki, Takao (Department of Physical Therapy, Aomori University of Health and Welfare) Lee, Sang-Kil (Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University) Kang, Tae-Young (College of Veterinary Medicine, Jeju National University) Hong, Yong-Geun (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University)
저널정보
한국동물번식학회 한국동물번식학회지 한국동물번식학회지 제34권 제2호
발행연도
2010.1
수록면
81 - 88 (8page)

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Our objective of current study was to investigate the development of bone and heart in association with diabetes mellitus (DM). DM was induced by administering an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) to 4-week-old Sprague-Dawley rats. Body weight and blood glucose were monitored, and rats were sacrificed after 2 or 5 weeks. The left ventricle (LV), including the interventricular septum, was weighed, and body weight and tibial bone length were assessed. Young diabetic rats showed reduced growth in terms of tibial length and body weight compared to controls. Moreover, diabetic males showed more significant growth suppression and reduced LV size than diabetic females. Morphometric analysis of tibiae from diabetic rats revealed suppressed bone growth at 2 and 5 weeks, with no difference between genders. STZ-induced diabetes decreased bone growth and retarded pre-pubertal heart development. As a result, diabetes may increase cardiovascular risk factors and lead to eventual heart failure. Therefore, new therapeutic approaches are required for diabetic children exhibiting growth retardation. Heart growth factor, exercise, and cardiopulmonary physical therapy may be required to promote heart development and physiological function.

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