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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : Diabetic nephropathy is one of the most significant chronic complications of diabetes. Advanced glycation end products (AGEs) have been implicated in the development of diabetic nephropathy. GS-E3D is an enzymatic modified red ginseng extract by pectin lyase and has an increased concentration of the ginsenoside Rd compared to an unmodified red ginseng extract. In this study, we evaluated the preventive effects of GS-E3D on renal dysfunction in the type 2 diabetic db/db mice. Methods : GS-E3D (100 or 250 mg/kg body weight per day) was given to db/db mice through oral gavage for 6 weeks. Body weight and blood glucose levels were examined. At the end of the experiment, albuminuria was measured. The renal tissues were collected for histological examination, and immunohistochemical staining was used to detect renal accumulation of AGEs and podocyte loss Results : In the db/db mice, severe hyperglycemia developed, and albuminuria was significantly increased. Diabetes induced markedly morphological alterations to the renal glomerular cells. AGE accumulations and podocyte loss were detected in renal glomeruli. No difference in blood glucose levels was noted between GS-E3D-treated and vehicletreated diabetic db/db mice. However, GS-E3D treatment significantly reduced albuminuria and AGE accumulations in diabetic mice. Moreover, the loss of podocytes was restored by GS-E3D treatment. Conclusions : GS-E3D might be beneficial for the treatment of diabetic nephropathy. The ability of GS-E3D on to attenuate albuminuria and podocyte dysfunction in the db/db mice may be mediated by the inhibition of AGE accumulation.
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참고문헌 (41)
참고문헌 신청
White KE / 2000 / Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease / J Am Soc Nephrol 11:1667~1673
Mauer SM / 1984 / Structural-functional relationships in diabetic nephropathy / The Journal of clinical investigation 74:1143~1155
Zhang Y / 2007 / Effects of mycophenolate mofetil, valsartan and their combined therapy on preventing podocyte loss in early stage of diabetic nephropathy in rats / Chinese medical journal 120:988~995
Pagtalunan ME / 1997 / Podocyte loss and progressive glomerular injury in type II diabetes / The Journal of clinical investigation 99:342~348
Meyer TW / 1999 / Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria / Diabetologia 42:1341~1344
Mauer SM / 1984 / Structural-functional relationships in diabetic nephropathy / The Journal of clinical investigation 74:1143~1155
Zhang Y / 2007 / Effects of mycophenolate mofetil, valsartan and their combined therapy on preventing podocyte loss in early stage of diabetic nephropathy in rats / Chinese medical journal 120:988~995
Pagtalunan ME / 1997 / Podocyte loss and progressive glomerular injury in type II diabetes / The Journal of clinical investigation 99:342~348
Meyer TW / 1999 / Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria / Diabetologia 42:1341~1344
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