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논문 기본 정보

자료유형
학술저널
저자정보
Chul-Min Park (Mokpo National University) Oh Jin Min (Mokpo National University) Min-Seok Kim (Korea Institute of Toxicology) Bhesh Raj Sharma (Mokpo National University) Dong Wook Kim (Mokpo National University) Dong Young Rhyu (Mokpo National University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.28 No.4
발행연도
2022.12
수록면
161 - 167 (7page)
DOI
10.20307/nps.2022.28.4.161

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Obesity is a complex metabolic disorder that increases the risk for type 2 diabetes, hyperlipidemia, hypertension, and atherosclerosis. In this study, we evaluated the anti-obesity effects of Nelumbo nucifera leaf (NL) extract in 3T3-L1 adipocytes and obese db/db mice. NL extract among various parts (leaf, seed, and root) of N. nucifera most effectively reduced adipogenesis via inhibiting CCAAT enhancer binding protein α (C/EBPα) and peroxisome proliferator activated receptor γ (PPARγ) expression in 3T3-L1 adipocytes. The addition of NL extract enhanced the protein expression of uncoupling protein 2 (UCP2) as compared to untreated 3T3-L1 adipocytes. The oral administration of NL extract (100 mg/kg BW) significantly reduced food efficacy ratio, body weight, and face or total cholesterol level in obese d b /db mice. Also, administration of NL extract significantly decreased adipocyte size and C/EBPα or PPARγ expression in the adipose tissues as compared with control (obese db/db mice). Therefore, our results suggest that NL extract among various parts of N. nucifera could be used as a functional food ingredient for the prevention and treatment of metabolic diseases including obesity and diabetes.

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Abstract
Introduction
Experimental
Results and Discussion
References

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