지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 13 (13page)
이용수
초록· 키워드
오류제보하기
Objective : Soybeans of Canavalia gladiata(CG) and root of Arctium lappa(AL) have been reported to have anti-inflammatory, antioxidant effect. However, the immunoregulatory mechanisms of its combinational prescription remain a matter of considerable debate. In the current study, we investigated whether CG and AL and its combinational prescription(CG+AL) regulate immune system using chronic immobilization-stress mouse model. Methods : C57BL/6J mice fixed for 2 hours into immobilization tube after CG, AL, CG+AL oral administration after 2 hours daily for 21 days. After every experiment has ended the C57BL/6J mice were sacrificed on 22 days. The production of Serotonin and Cortisol, lgA were observed by ELISA method, The proportion of immune cells such as T/B cell and macrophage, NK cell were measured by FACS. Then, Real-time PCR was performed to measure the mRNA expression of Inflammatory cytokines(IL-1beta, IL-6, TNF-a) and T cell activation cytokines(IL-2, IL-10, IFN-gamma, IL-12p35 / p40). Result : When chronic immobilization-stress mouse model were treated with CG+AL(1:4), the expression of mRNA were significantly decreased at the Inflammatory cytokines(IL-1beta, IL-6, TNF-a). While, the levels of mRNA were significantly increased at immune T cell activation cytokines. Additionally, CG+AL(1:4) combinational prescription group enhanced immune cells such as T/B cell and macrophage, NK cell. Furthermore, the Immuno-fluorescence result of brain tissue can confirm that CG+AL(1:4) group significantly increased the BDNF expression. Conclusion : These result suggest that CG+AL(1:4) combinational prescription has Immune System enhancement via stress-mediated immunocyte.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
알레르기 후기 반응 염증 억제효과에 관한 淸肌散의실험적 연구
한방안이비인후피부과학회지
2016 .01
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
종양이식 생쥐모델에서 도두(刀豆), 우방근(牛蒡根) 추출물의 대장암 억제 효과
대한본초학회지(본초분과학회지)
2017 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Inflammatory Cytokines and Their Prognostic Ability in Cases of Major Burn Injury
Annals of Laboratory Medicine
2015 .01
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells
Natural Product Sciences
2018 .09
-
Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
Immune Network
2018 .04
-
Regulation of Osteoclast Differentiation by Cytokine Networks
Immune Network
2018 .02
-
IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases
Immune Network
2017 .10
-
T helper 1 & 2 cytokine profiles in patients with Kawasaki disease
Korean Circulation Journal
2015 .01
-
만성 위염에 대한 추나요법의 효과: 체계적 문헌고찰
척추신경추나의학회지
2017 .01
-
Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
The Korean Journal of Physiology & Pharmacology
2021 .09
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients
Annals of Dermatology
2017 .01
-
IL-17A and Th17 Cells Contribute to Endometrial Cell Survival by Inhibiting Apoptosis and NK Cell Mediated Cytotoxicity of Endometrial Cells via ERK1/2 Pathway
Immune Network
2023 .04
-
호마자 추출물이 NC/Nga 생쥐의 아토피 피부염에 미치는 영향
대한한방소아과학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0