지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that play a significant role in synaptic plasticity, learning, memory, and other behaviors. NMDARs are composed of various subunits and display unique properties depending on their subunit composition. The GluN3A subunit is thought to suppress NMDAR activity, however its exact function has not been well studied. Thus, we designed a transgenic mice overexpressing GRIN3A to assess the role of this gene on various behaviors. GRIN3A-overexpressing mice were subjected to an array of behavioral experiments including locomotor activity test, rota-rod test, elevated plus-maze (EPM) test, and Y-maze test. GRIN3A-overexpressing mice displayed hypoactivity but no effects on the rota-rod test, EPM test and Y-maze test. The GRIN3A-overexpressing mice that we have created can be utilized in elucidating the role of the GRIN3A gene and its product, the GluN3A subunit of NMDARs, on various behaviors associated with neuropsychiatric disorders, such as ADHD, and in finding possible therapeutic targets for these disorders.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Cull-Candy, S / 2001 / NMDA receptor VC subunits: diversity, development and disease / Curr. Opin. Neurobiol 11:327
Perez-Otano, I / 2004 / Learning from NMDA receptor trafficking: Clues to the development and maturation of glutamaterginc synapses / Neurosignals 13:175
Henson, M. A / 2010 / Influence of the NR3A subunit on NMDA receptor functions. / Prog. Neurobiol 91:23
Traynelis, S. F / 2010 / Glutamate receptor ion channels:structures regulation and function / Pharmacol. Rev 62:405
Paoletti, P / 2013 / NMDA recptor subunit diversity: impact on receptor properties, synaptic plasticity and disease / Nature Rev. Neurosci 14:383
Perez-Otano, I / 2004 / Learning from NMDA receptor trafficking: Clues to the development and maturation of glutamaterginc synapses / Neurosignals 13:175
Henson, M. A / 2010 / Influence of the NR3A subunit on NMDA receptor functions. / Prog. Neurobiol 91:23
Traynelis, S. F / 2010 / Glutamate receptor ion channels:structures regulation and function / Pharmacol. Rev 62:405
Paoletti, P / 2013 / NMDA recptor subunit diversity: impact on receptor properties, synaptic plasticity and disease / Nature Rev. Neurosci 14:383
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