소음성 난청 생쥐 모델에서 방사상 미로검사

박소영; 백상아; Huerxidan Sikandaner; 여상원; 박시내

추천

검색

자료유형: 학술저널

저자정보: 박소영 백상아 Huerxidan Sikandaner 여상원 박시내

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제58권 제6호

발행연도: 2015.1

수록면: 395 - 401 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives Hearing loss has been hypothesized to contribute to cognitive decline in the elderly. However, earlier studies yielded conflicting results, and the causal relationship has not been elucidated to date. In the present study, the authors set up a radial maze apparatus for assessment of cognition in mice, and investigated the relationship between cognition and hearing loss that occur immediately after noise exposure. Materials and Method Spatial learning and memory were assessed in male C57BL/6 mice with or without hearing loss using an unconfined, partially-baited, 8-arm radial maze with different arm length (25 or 50 cm). The performance indicators included total trial time, latency, reference memory error, working memory error, and correct entry ratio. Mice in the hearing loss group were exposed to 60 min of 110 dB white noise for 14 days, and then auditory brainstem response thresholds were measured. Results Mice showed better performances in a 25 cm-arm radial maze than in a 50 cm-arm maze. The control and the hearing loss groups exhibited similar performance curves, except for the working memory curve in 25 cm-arm radial maze. Hearing-impaired mice were better at working memory tasks than the control mice, probably due to an early cognitive compensatory mechanism. Conclusion A radial maze with 25 cm arm is appropriate for the test of learning and memory in mice. Acute hearing loss after noise exposure was not associated with decreased cognition. Further follow-up research has been planned to find the effect of long-term hearing loss on cognition and the mechanism by which these two domains are connected.

#Aging #Cognitive decline #Memory #Noise #Spatial learning

참고문헌 (27)

참고문헌 신청

Cheng L / 2011 / Moderate noise induced cognition impairment of mice and its underlying mechanisms / Physiol Behav 104(5):981~988

Moxon KA / 1999 / Multiple single units and population responses during inhibitory gating of hippocampal auditory response in freelymoving rats / Brain Res 825(1-2):75~85

Anstey KJ / 2001 / Two-year decline in vision but not hearing is associated with memory decline in very old adults in a population-based sample / Gerontology 47 (5) : 289 ~ 2

Baltes PB / 1997 / Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging? / Psyc

Boyle PA / 2008 / Processing resources reduce the effect of Alzheimer pathology on other cognitive systems / Neurology 70 (17) : 1534 ~ 1542

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!