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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제7호
- 발행연도
- 2008.1
- 수록면
- 905 - 910 (6page)
이용수
초록· 키워드
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Myeloperoxidase catalyzes the formation of hypochlorous acid (HOCl) via reaction of $H_2O_2$ with $Cl^-$ions. Although HOCl plays a major role in the human immune system by killing bacteria and other invading pathogens, excessive generation of this oxidant causes damage to tissues. Exposure of HeLa cells to HOCl decreased viability, inactivated antioxidant enzymes, damaged mitochondria, and modulated cellular redox status. HOCl also induced significant increases in cellular oxidative damage reflected by lipid peroxidation, protein oxidation, and DNA damage. HOCl-mediated oxidative damage to HeLa cells may perturb the cellular antioxidant defense mechanisms and subsequently lead to a pro-oxidant state.
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