지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. In this study we found that apigenin stimulated melanin synthesis in a dose-dependent manner in B16 murine melanoma cells. Since in our previous study $K^+$-$Cl^-$-cotransport (KCC) has been shown to mediate the mechanism of action of apigenin in neuronal cells, we further investigated the role of KCC in the melanogenesis-stimulating effect of apigenin in B16 cells. At nontoxic concentrations apigenin induced $Cl^-$-dependent $K^+$ efflux, a hallmark of KCC activity, which was markedly prevented by a specific KCC inhibitor R-(+)-[(2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid (DIOA). These results indicate that KCC is functionally present, and activated by apigenin in the B16 cells. In addition, the apigenin-induced stimulation of melanogenesis was also significantly inhibited by DIOA. NEthylmaleimide (NEM), a known KCC activator, induced $Cl^-$ efflux and stimulated melanogenesis in a concentration-dependent fashion. Both effects of NEM were significantly inhibited by DIOA. Taken together, these results suggest that apigenin can modulate melanogenesis through the activation of a membrane ion transporter, KCC in B16 cells. These results further suggest that apigenin may be a good candidate in the therapeutic strategy for hypopigmentation disorders, such as vitiligo.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Peterson, J. / 1988 / Flavonoids: dietary occurrence and biochemical activity / Nutr. Res 18:1995
Je-Hyuk Lee / 2007 / Anti-Inflammatory Mechanisms of Apigenin: Inhibition of Cyclooxygenase-2 Expression, Adhesion of Monocytes to Human Umbilical Vein Endothelial Cells, and Expression ofCellular Adhesion Molecules / Archives of Pharmacal Research 30(10):1318~1327
Rezai-Zadeh, K. / 2008 / Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression / J. Neuroinflammation 5:41
Psotová, J. / 2004 / anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin / Phytother. Res 18:516
Caltagirone, S. / 2000 / Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential / Int. J. Cancer 87:595
Je-Hyuk Lee / 2007 / Anti-Inflammatory Mechanisms of Apigenin: Inhibition of Cyclooxygenase-2 Expression, Adhesion of Monocytes to Human Umbilical Vein Endothelial Cells, and Expression ofCellular Adhesion Molecules / Archives of Pharmacal Research 30(10):1318~1327
Rezai-Zadeh, K. / 2008 / Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression / J. Neuroinflammation 5:41
Psotová, J. / 2004 / anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin / Phytother. Res 18:516
Caltagirone, S. / 2000 / Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential / Int. J. Cancer 87:595
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
B16 흑색종세포에서 아피제닌에 의한 멜라닌 합성에 미치는 NADPH 산화효소-유래 활성산소종의 역할
약학회지
2011 .01
-
Involvement of K-Cl-Cotransport in the Apigenin-Induced Generation of Reactive Oxygen Species in IMR-32 Human Neuroblastoma Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
-
자궁경부암 세포주에서 Apigenin에 의한 세포사 유도
Obstetrics & Gynecology Science
2008 .01
-
Anti-inflammatory Mechanisms of Apigenin: Inhibition of Cyclooxygenase-2 Expression, Adhesion of Monocytes to Human Umbilical Vein Endothelial Cells, and Expression of Cellular Adhesion Molecules
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Apigenin induces apoptosis through inhibit of MAPK signaling in A375SM and A375P melanoma cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Mechanism of Apoptosis Induced by Apigenin in HepG2 Human Hepatoma Cells: Involvement of Reactive Oxygen Species Generated by NADPH Oxidase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
흰쥐에서 아피제닌이 타목시펜의 생체이용률에 미치는 영향
약학회지
2010 .01
-
인체 간암세포에서 Apigenin에 의한 TRAIL 유도 Apoptosis의 증진 효과
약학회지
2011 .01
-
Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
Apigenin Inhibits Tumor Necrosis Factor-α-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Inhibitory mechanism of rat aortic vascular smooth muscle cell proliferation by apigenin
대한약학회 학술대회
2001 .01
-
Vasorelaxation and Antiproliferation of Apigenin
대한약학회 학술대회
2000 .01
-
멜라닌 생성과 그 조절
대한화장품학회 심포지움
1996 .01
-
Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
-
B16 흑색종세포에서 아라키돈산에 의한 멜라닌 합성 촉진 효과에 미치는 칼륨-염소이온-수송체의 역할
약학회지
2016 .01
-
Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
Toxicological Research
2019 .04
-
The Promotive Effects of Antioxidative Apigenin on the Bioavailability of Paclitaxel for Oral Delivery in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0