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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제10호
- 발행연도
- 2007.1
- 수록면
- 1,318 - 1,327 (10page)
이용수
초록· 키워드
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The aim of this study was to clarify the anti-inflammatory mechanism of apigenin. Apigenin inhibited the collagenase activity involved in rheumatoid arthritis (RA) and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a dose dependent manner in RAW 264.7 macrophage cells. Pretreatment with apigenin also attenuated LPS-induced cyclooxygenase-2 (COX-2) expression. In addition, apigenin profoundly reduced the tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)-induced adhesion of monocytes to HUVEC monolayer. Apigenin significantly suppressed the TNF-${\alpha}$-stimulated upregulation of vascular cellular adhesion molecule-1 (VCAM-1 )-, intracellular adhesion molecule-1 (ICAM-1)-, and E-selectin-mRNA to the basal levels. Taken together, these results suggest that apigenin has significant anti-inflammatory activity that involves blocking NO-mediated COX-2 expression and monocyte adherence. These results further suggest that apigenin may be useful for therapeutic management of inflammatory diseases.
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자궁경부암 세포주에서 Apigenin에 의한 세포사 유도
Obstetrics & Gynecology Science
2008 .01
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The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
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Involvement of K-Cl-Cotransport in the Apigenin-Induced Generation of Reactive Oxygen Species in IMR-32 Human Neuroblastoma Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
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Mechanism of Apoptosis Induced by Apigenin in HepG2 Human Hepatoma Cells: Involvement of Reactive Oxygen Species Generated by NADPH Oxidase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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Manassantin A and B Isolated from Saururus chinensis Inhibit $TNF-{\alpha}-Induced$ Cell Adhesion Molecule Expression of Human Umbilical Vein Endothelial Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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흰쥐에서 아피제닌이 타목시펜의 생체이용률에 미치는 영향
약학회지
2010 .01
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Apigenin Inhibits Tumor Necrosis Factor-α-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
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γ-Irradiation Induced Adhesion Molecules are Reduced by Vitamin C in Human Endothelial Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
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Apigenin induces apoptosis through inhibit of MAPK signaling in A375SM and A375P melanoma cells
한국실험동물학회 학술발표대회 논문집
2018 .01
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B16 흑색종세포에서 아피제닌에 의한 멜라닌 합성 촉진효과에 미치는 칼륨-염소이온수송체의 역할
약학회지
2008 .01
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Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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인체 간암세포에서 Apigenin에 의한 TRAIL 유도 Apoptosis의 증진 효과
약학회지
2011 .01
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Inhibition of $\gamma$-Irradiation Induced Adhesion Molecules and NO Production by Alginate in Human Endothelial Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
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Inhibitory mechanism of rat aortic vascular smooth muscle cell proliferation by apigenin
대한약학회 학술대회
2001 .01
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Vasorelaxation and Antiproliferation of Apigenin
대한약학회 학술대회
2000 .01
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Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
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Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
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Korean Red Ginseng Extract inhibits Tumor Necrosis Factor-alpha-induced Monocyte Adhesion in the Human Endothelial Cells
Journal of Ginseng Research
2008 .09
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Effect of Rutin on Adhesion Molecules Expression and NO Production Induced by $\gamma$-irradiation in Human Endothelial cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
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