지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제14권 제3호
- 발행연도
- 2006.1
- 수록면
- 137 - 142 (6page)
이용수
초록· 키워드
오류제보하기
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. In this study we investigated the role of apigenin in the production of reactive oxygen species (ROS) through the modulation of activity of $K^+-Cl^-$-cotransport (KCC) in IMR-32 human neuroblastoma cells. Apigenin induced $Cl^-$-dependent $K^+$ efflux, a hallmark of KCC activity, which was markedly prevented by different kinds of KCC inhibitors (calyculin-A, genistein and $BaCl_2$). These results indicate that KCC is functionally present, and activated by apigenin in the IMR-32 cells. Treatment with apigenin also induced a sustained increase in the level of intracellular ROS. The KCC inhibitors also significantly inhibited the apigenin-induced ROS generation. Taken together, these results suggest that apigenin can modulate ROS generation through the activation of a membrane ion transporter, KCC. These results further suggest that the alteration of KCC activity may play a role in the mechanism of degenerative diseases and/or carcinogenesis in neuronal tissues through the regulation of ROS production.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mechanism of Apoptosis Induced by Apigenin in HepG2 Human Hepatoma Cells: Involvement of Reactive Oxygen Species Generated by NADPH Oxidase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
B16 흑색종세포에서 아피제닌에 의한 멜라닌 합성 촉진효과에 미치는 칼륨-염소이온수송체의 역할
약학회지
2008 .01
-
자궁경부암 세포주에서 Apigenin에 의한 세포사 유도
Obstetrics & Gynecology Science
2008 .01
-
Anti-inflammatory Mechanisms of Apigenin: Inhibition of Cyclooxygenase-2 Expression, Adhesion of Monocytes to Human Umbilical Vein Endothelial Cells, and Expression of Cellular Adhesion Molecules
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
B16 흑색종세포에서 아피제닌에 의한 멜라닌 합성에 미치는 NADPH 산화효소-유래 활성산소종의 역할
약학회지
2011 .01
-
The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Apigenin induces apoptosis through inhibit of MAPK signaling in A375SM and A375P melanoma cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
인체 간암세포에서 Apigenin에 의한 TRAIL 유도 Apoptosis의 증진 효과
약학회지
2011 .01
-
흰쥐에서 아피제닌이 타목시펜의 생체이용률에 미치는 영향
약학회지
2010 .01
-
Apigenin Inhibits Tumor Necrosis Factor-α-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Inhibitory mechanism of rat aortic vascular smooth muscle cell proliferation by apigenin
대한약학회 학술대회
2001 .01
-
Vasorelaxation and Antiproliferation of Apigenin
대한약학회 학술대회
2000 .01
-
Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
-
The Promotive Effects of Antioxidative Apigenin on the Bioavailability of Paclitaxel for Oral Delivery in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
Construction and analysis of painting probe for HSR in IMR-32 human neuroblastoma cells
대한체질인류학회 학술대회 연제 초록
1996 .05
-
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
Toxicological Research
2019 .04
-
Clinical and Angiographic Predictors of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction
Yonsei Medical Journal
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0