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To investigate effect of caffeic acid on the intracellular reactive oxygen species production, we used DHE for intracellular superoxide anion production, DCF for intracellular ${H_2}{O_2}$ production and DHR for intracellular hydroperoxide production in Raw 264.7 cells. DPPH assay showed that antioxidant activity of caffeic acid with 39.5 ${\mu}M$ of ${IC}_{50}$ values was similar to that of ascorbic acid with 41.3 ${\mu}M$ of ${IC}_{50}$ values. Caffeic acid dose-dependently inhibited silica-induced ${H_2}{O_2}$ and hydroperoxide production but did not affect superoxide anion production in Raw 264.7 cells, which suggest that antioxidant effect of caffeic acid acts on the post-step of superoxide anion. On the other hand, caffeic acid showed a potent antioxidant effect in $lCuSO_4$-induced lipid peroxidation. Furthermore, plasma superoxide dismutase activity (3.43${\pm}$0.23 U/ml) in 10 mg/kg caffeic acid-fed mice was significantly higher than that (2.32${\pm}$0.24 U/ml) of control. From the above results, it is referred that caffeic acid appears to have potent anti-oxidant activity in both cell system and in vivo system.
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참고문헌 (20)
참고문헌 신청
Kuo, W. N. / 1999 / Denitration of peroxynitrite-treated proteins by protein nitratases from dog prostate / Biochem. Mol. Biol. Int 47:1061
Lee, J. Y. / 2004 / Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC / Phytochemistry 65:3033
Beyer, G / 2003 / Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidaseinduced toxicity in cultivated human cells / Planta. Med 69:1125
Okutan, H. / 2005 / Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart / Clin. Biochem 38:191
Gurel, A. / 2004 / Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma / Physiol. Res 53:675
Lee, J. Y. / 2004 / Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC / Phytochemistry 65:3033
Beyer, G / 2003 / Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidaseinduced toxicity in cultivated human cells / Planta. Med 69:1125
Okutan, H. / 2005 / Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart / Clin. Biochem 38:191
Gurel, A. / 2004 / Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma / Physiol. Res 53:675
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