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Traditionally, Cham dang-gui (Angelica gigas Nakai) is one of the most popular herbal medicines in Asian countries including Korea. A. gigas has been used as a functional food product for treatment anemia, women's health care, a sedative, an anodyne or a tonic agent. Decursin and decursinol angelate isolated from the roots of A. gigas are pyranocoumarin compounds. Recently, as the global herbal medication market is increasing, investigations about pharmacological effects of decursin and decursinol angelate are rapidly increasing. We summarized previous studies about pharmacological effects of decursin and decursinol angelate, and reviewed relation with pharmacological effects of decursin and decursinol angelate on human disorder, focused on the approach for new drug development. Pharmacological effects of decursin and decursinol angelate were classified as anti-tumor activity, anti-bacterial activity, improvements of the circulating system, inhibition of cytochrome P-450 activity, anti-inflammation activity, anti-oxidant activity and cognitive-enhancing activites. The activity of A. gigas with improvement of the circulating system may have wide therapeutic potential for circulatory diseases, including diabetes, hyperlipidemia and atherosclerosis. Also, anti-inflammation activity A. gigas may be beneficial for the treatment and prevention of asthma, atopic dermatitis and rheumatism arthritis. This relation could potentially lead to the development of herbal new drugs. In order to development a new drug containing decursin and decursinol angelate, it is also necessary to consider the safety profile, and the information in this review would contribute to development a new drug from herbal medicine.
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Anti-Tumor Activities of Decursinol Angelate and Decursin from Angelica gigas
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
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참당귀(Angelica gigas) 뿌리 추출물로부터 (+)-Decursinol의 대량 제조 방법
약학회지
2006 .01
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Study on anti-angiogenic effects of fractionated Angelica gigas Nakai and its compound, decursin and, decursinol angelate
대한동의병리학회 학술대회논문집
2003 .07
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Evaluation of the Genotoxicity of Decursin and Decursinol Angelate Produced by Angelica gigas Nakai
Molecular & cellular toxicology
2009 .01
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Oral Acute and Subacute Toxicity Studies of Decursin and Decursinol Angelate of Angelica gigas Nakai
Molecular & cellular toxicology
2009 .01
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Antibacterial Coumarins from Angelica gigas Roots
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
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Effect of decursinol angelate on helper 17 T cell responses and colitis
한국실험동물학회 학술발표대회 논문집
2019 .07
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당뇨유발 흰쥐에서 당수송 인자와 AMP-Activated Protein Kinase의 조절에 대한 데커신과 데커시놀 안젤레이트의 효과
약학회지
2011 .01
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Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
The Korean Journal of Physiology & Pharmacology
2019 .01
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Decursinol angelate ameliorates dextran sodium sulphate-induced colitis by modulating type 17 helper T cell responses
한국실험동물학회 학술발표대회 논문집
2018 .01
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Decursin from Angelica gigas Nakai Blocks hKv1.5 Channel
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
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당귀 추출물의 피부 흡수 증가를 위한 마이크로에멀젼 조성
약학회지
2012 .01
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Validation of Analysis Methods of Decursin and Decursin angelate from Angelicae gigantis Radix by Reversed-phase Liquid Chromatography
대한약학회 학술대회
2003 .01
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