지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Diabetes has been one of major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has been focused as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK increases glucose uptake through independent insulin signal pathway. In this study, we investigated the anti-diabetic effect of Angelica gigas Nakai extract (AGNEX), a mixture of decursin and decursinol angelate (53 : 47), decursin and decursinol angelate on blood glucose, glucose transport (GLUT) and AMPK expression levels in streptozotocin (STZ)-induced diabetic rats. To induce diabetes, 50 mg/kg of STZ was injected via i.v. route and AGNEX 2 mg/kg (STZ+AG), decursin 2 mg/kg (STZ+D), decursinol angelate 2 mg/kg (STZ+DA), and metformin 100 mg/kg (STZ+M) were administered orally for 21 days. STZ+DA group showed a significant decrease in fasting blood glucose levels compared to the other groups. Decursinol angelate significantly upregulated expression of glucose transporter 4 (GLUT4) and phosphorylation of AMPK (p-AMPK) in skeletal muscle of rats. In pancreas of rats, decursinol angelate significantly increased expression of GLUT2 through down-regulation of p-AMPK. In addition to the result of pancreatic islets morphology, AGNEX, decursin, decursinol angelate, and metformin treated group recovered ${\beta}$-cell damage by hyperglycemia. These results indicate that decursinol angelate might be a potential anti-diabetic agent and AGNEX could be useful in the treatment of diabetes mellitus.
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참고문헌 (26)
참고문헌 신청
Delarue, J / 2007 / Free fatty acids and insulin resistance 10:142
김응진 / 2005 / 제 3판 당뇨병학 / 대한당뇨병학회 310
Arner, P / 2002 / Insulin resistance in type 2 diabetes: role of fatty acids / Diabetes Metab. Res. Rev 18:S5
Chomczynski, P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction / Anal. Biochem 162:156
Ziel, F. H / 1988 / Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats / Diabetes 37:885
김응진 / 2005 / 제 3판 당뇨병학 / 대한당뇨병학회 310
Arner, P / 2002 / Insulin resistance in type 2 diabetes: role of fatty acids / Diabetes Metab. Res. Rev 18:S5
Chomczynski, P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction / Anal. Biochem 162:156
Ziel, F. H / 1988 / Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats / Diabetes 37:885
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