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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제1호
- 발행연도
- 2019.1
- 수록면
- 29 - 35 (7page)
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Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of this plant. In this study, we evaluated the inhibitory activity and related mechanism of action of decursin against glioblastoma cell line. Decursin demonstrated cytotoxic effects on U87 and C6 glioma cells in a dose-dependent manner but not in primary glial cells. Additionally, decursin increased apoptotic bodies and phosphorylated JNK and p38 in U87 cells. Decursin also down-regulated Bcl-2 as well as cell cycle dependent proteins, CDK-4 and cyclin D1. Furthermore, decursin-induced apoptosis was dependent on the caspase activation in U87 cells. Taken together, our data provide the evidence that decursin induces apoptosis in glioblastoma cells, making it a potential candidate as a chemotherapeutic drug against brain tumor.
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참고문헌 (32)
참고문헌 신청
Heo J / 2013 / DONGUIBOGAM Treasured Mirror of Eastern Medicine Part I Internal Bodily Elements / Chin Young
Ahn MJ / 2008 / The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry / J Pharm Biomed Anal 46:258~266
Rhim JS / 2000 / In vitro human cell culture models for the study of prostate cancer / Prostate Cancer Prostatic Dis 3:229~235
Yim D / 2005 / A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells / Cancer Res 65:1035~1044
de Groot JF / 2015 / High-grade gliomas / Continuum(Minneap Minn) 21:332~344
Ahn MJ / 2008 / The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry / J Pharm Biomed Anal 46:258~266
Rhim JS / 2000 / In vitro human cell culture models for the study of prostate cancer / Prostate Cancer Prostatic Dis 3:229~235
Yim D / 2005 / A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells / Cancer Res 65:1035~1044
de Groot JF / 2015 / High-grade gliomas / Continuum(Minneap Minn) 21:332~344
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