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Effects of Direct Moxibustion Applied to EX-LE4 and EX-LE5 on the Pain Behavior and Expression of TRPM8 in the Rat Model of Ambient Cold Exposed Osteoarthritis
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추위에 노출된 슬관절염 모델에서 내슬안, 외슬안 직접구가 통증행동과 TRPM8 발현에 미치는 영향

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Type
Academic journal
Author
Ji, Byeong Uk (부산대학교 한의학전문대학원 한의과학과) Kim, Yiquot (부산대학교 한의학전문대학원 한의과학과) Lee, Ji Eun (부산대학교 건강노화 한의과학 연구센터) Koo, Sungtae (부산대학교 한의학전문대학원 한의과학과)
Journal
경락경혈학회 Korean Journal of Acupuncture Korean journal of acupuncture 제33권 제4호 KCI Accredited Journals
Published
2016.1
Pages
204 - 212 (9page)

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Effects of Direct Moxibustion Applied to EX-LE4 and EX-LE5 on the Pain Behavior and Expression of TRPM8 in the Rat Model of Ambient Cold Exposed Osteoarthritis
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Objectives : The aim of the study is to investigate the effects of moxibustion on the pain behavior and expression of TRPM8 in the dorsal root ganglion(DRG) in the rat model of ambient cold(AC) exposed osteoarthritis(OA). Methods : OA was induced by the injection of $50{\mu}l$ of 2% monosodium iodoacetate(MIA) into the knee joint cavity. To examine the level of pain, weight bearing forces(WBFs) of affected limb was measured. For the AC exposure, the animals were housed in 6 h/day at $4^{\circ}C$ for 14 days after MIA injection. Moxibustion treatment was performed at EX-LE4 and EX-LE5 with 5 cons(1, 7 or 10 mg) per day for 13 days from 5 days after MIA injection. The expressions of TRPM8 in DRG were measured by western blotting analysis. Results : The WBFs of MIA-AC group were decreased significantly compared to MIA group at 2, 3, 6, 7, 8 and 9 days after arthritis induction. After the first 6 h-AC exposure, expressions of TRPM8 in MIA-AC group were increased significantly compared to those of naive group. After moxibustion treatment, only the WBFs of 7 mg treated group were restored significantly. Moreover, the over-expressions of TRPM8 were attenuated by the moxibustion treatment in AC exposed rats. Conclusions : The data suggest that AC can increase arthritic knee pain via up-regulated TRPM8 and moxibustion treatment improve the arthritic pain via modulation of TRPM8 expression in DRG in the rat model of AC exposed MIA induced arthritis.
#monosodium iodoacetate induced arthritis #ambient cold #TRPM8 channel #EX-LE4 #EX-LE5 #moxibustion

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Felson DT / 1988 / Epidemiology of hip and knee osteoarthritis / Epidemiologic reviews 10:1~28 google schola Andrianakos AA / 2006 / Prevalence of symptomatic knee, hand, and hip osteoarthritis in Greece. The ESORDIG study / The Journal of rheumatology 33:2507~2513 google schola Martel-Pelletier J / 2004 / Pathophysiology of osteoarthritis / Osteoarthritis and cartilage 12(Suppl A):S31~S33 google schola Zhang W / 2008 / OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines / Osteoarthritis and cartilage 16:137~162 google schola Kim HA / 2003 / Use of complementary and alternative medicine by arthritis patients in a university hospital clinic serving rheumatology patients in Korea / Rheumatology international 23:277~281 google schola

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