Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells

Lin, Chang-Ming; Ma, Ji-Min; Zhang, Li; Hao, Zong-Yao; Zhou, Jun; Zhou, Zhen-Yu; Shi, Hao-Qiang; Zhang, Yi-Fei; Shao, En-Ming; Liang, Chao-Zhao

추천

검색

자료유형: 학술저널

저자정보: Lin, Chang-Ming (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Ma, Ji-Min (Emergency medical center, The Central Hospital of Maanshan The Affiliated Hospital of Wannan Medical College) Zhang, Li (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Hao, Zong-Yao (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Zhou, Jun (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Zhou, Zhen-Yu (The First people's hospital of Suqian) Shi, Hao-Qiang (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Zhang, Yi-Fei (Department of Urology, The First Affiliated Hospital of Anhui Medical University) Shao, En-Ming (The Municipal people's hospital of Maanshan) Liang, Chao-Zhao (Department of Urology, The First Affiliated Hospital of Anhui Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,469 - 4,475 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Transient receptor potential melastain 7 (TRPM7) is a bifunctional protein with dual structure of both ion channel and protein kinase, participating in a wide variety of diseases including cancer. Recent researches have reported the mechanism of TRPM7 in human cancers. However, the correlation between TRPM7 and prostate cancer (PCa) has not been well studied. The objective of this study was to investigate the potential the role of TRPM7 in the apoptosis of PC-3 cells, which is the key cell of advanced metastatic PCa. In this study, we demonstrated the influence and potential function of TRPM7 on the PC-3 cells apoptosis induced by TNF-related apoptosis inducing-ligand (TRAIL). The study also found a novel up-regulated expression of TRPM7 in PC-3 cells after treating with TRAIL. Suppression of TRPM7 by TRPM7 non-specific inhibitors ($Gd^{3+}$ or 2-aminoethoxy diphenylborate (2-APB) ) not only markedly eliminated TRPM7 expression level, but also increased the apoptosis of TRAIL-treated PC-3 cells, which may be regulated by the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway accompany with up-regulated expression of cleaved Caspase-3, (TRAIL-receptor 1, death receptors 4) DR4, and (TRAIL-receptor 2, death receptors 5) DR5. Taken together, our findings strongly suggested that TRPM7 was involved in the apoptosis of PC-3 cells induced by TRAIL, indicating that TRPM7 may be applied as a therapeutic target for PCa.

#Transient receptor potential melastain 7 #TRPM7) #Prostate Cancer #PCa) #PC-3 cells #TNF-related apoptosis inducing #ligand #TRAIL) Apoptosis #TRPM7 inhibitors

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!