지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 169 - 174 (6page)
이용수
초록· 키워드
오류제보하기
Transient receptor potential melastatin 8 (TRPM8) plays a crucial role in innocuous cool sensation, acute cold pain and cold-induced hyperalgesia during pathologic conditions. To help understand TRPM8-mediated cold perception in the dental pulp and periodontal tissues, we examined the distribution of TRPM8-immunopositive (+) axons in molar and incisor pulp and periodontal tissues using transgenic mice expressing a genetically encoded axonal tracer in TRPM8+ neurons.
In the radicular pulp of the molar teeth, a small number of TRPM8+ axons were observed. TRPM8+ axons branched frequently and extensively in the core of coronal pulp, forming a network in the peripheral pulp. Some TRPM8+ axons ascended between odontoblasts and were observed in the dentinal tubule. TRPM8+ axons were linear-shaped in the radicular pulp, whereas many TRPM8+ axons showed portions shaped like beads connected with thin axonal stands at the peripheral pulp. TRPM8 was densely expressed in the bead portions. In the incisor pulp, TRPM8+ axons were occasionally observed in the core of the coronal pulp and rarely observed at the peripheral pulp. TRPM8+ axons were occasionally observed and showed a linear shape rather than a bead-like appearance in the periodontal ligament and lamina propria of the gingival tissue.
These findings, showing differential distribution of TRPM8+ axons between radicular and coronal portions of the molar pulp, between incisor and molar pulp, and between dental pulp and periodontal tissues, may reflect differential cold sensitivity in these regions.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ajay Dhaka / 2007 / TRPM8 Is Required for Cold Sensation in Mice / Neuron 54 (3) : 371 ~ 378
Andrea M. Peier / 2002 / A TRP Channel that Senses Cold Stimuli and Menthol / Cell 108 (5) : 705 ~ 715
Bashar Anas Alkhamrah / 2003 / The periodontal Ruffini endings in brain derived neurotrophic factor (BDNF) deficient mice. / Archives of Histology and Cytology 66 (1) : 73 ~
Byers MR / 1984 / Dental sensory receptors / Int Rev Neurobiol 25 : 39 ~ 94
David D. McKemy / 2002 / Identification of a cold receptor reveals a general role for TRP channels in thermosensation / Nature 416 (6876) : 52 ~ 58
Andrea M. Peier / 2002 / A TRP Channel that Senses Cold Stimuli and Menthol / Cell 108 (5) : 705 ~ 715
Bashar Anas Alkhamrah / 2003 / The periodontal Ruffini endings in brain derived neurotrophic factor (BDNF) deficient mice. / Archives of Histology and Cytology 66 (1) : 73 ~
Byers MR / 1984 / Dental sensory receptors / Int Rev Neurobiol 25 : 39 ~ 94
David D. McKemy / 2002 / Identification of a cold receptor reveals a general role for TRP channels in thermosensation / Nature 416 (6876) : 52 ~ 58
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Morphological Analysis of the Myelinated Parent Axons that Innervate Rat Upper Molar Pulps in the Trigeminal Ganglion
International Journal of Oral Biology
2015 .01
-
Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
치수 내 신경분포에 관한 고찰
한국구강보건과학회지
2022 .06
-
Ultrastructure of Substance P Immunopositive Axons in the Human Dental Pulp
International Journal of Oral Biology
2018 .01
-
영지버섯추출물 및 에르고스테롤의 냉감 수용체 TRPM8 (Transient Receptor Potential Cation Channel Melastatin Subtype 8) 발현 유도 효과
대한화장품학회지
2018 .01
-
Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells
Allergy, Asthma & Immunology Research
2020 .01
-
우식제거 과정에서 노출된 치수에 대한 치료방법 선택에 영향을 주는 요인에 대한 분석
대한치과의사협회지
2025 .02
-
TRPM7 as a potential diagnostic and prognostic marker of canine mammary gland tumors
한국실험동물학회 학술발표대회 논문집
2020 .07
-
추위에 노출된 슬관절염 모델에서 내슬안, 외슬안 직접구가 통증행동과 TRPM8 발현에 미치는 영향
Korean Journal of Acupuncture
2016 .01
-
Sensory and motor axons are different: implications for neurological disease
Annals of Clinical Neurophysiology
2017 .01
-
Evaluation of the relation between the pulp stones and direct restorations using cone beam computed tomography in a Turkish subpopulation
Restorative Dentistry and Endodontics
2021 .08
-
Development of a mouse model for pulp-dentin complex regeneration research: a preliminary study
Restorative Dentistry and Endodontics
2019 .01
-
미성숙 영구치의 치수치료
대한치과의사협회지
2019 .07
-
Direct Pulp Capping of an Immature Permanent Tooth with Caries and Pulp Exposure Using Mineral Trioxide Aggregate: A Case Report
International Journal of Clinical Preventive Dentistry
2020 .01
-
Effect of hypoxia on angiogenesis-related proteins in human dental pulp cells
International Journal of Oral Biology
2016 .01
-
미성숙 영구치의 치수재혈관화
대한치과의사협회지
2016 .08
-
Age Estimation by Radiological Measuring Pulp Chamber of Mandibular First Molar in Korean Adults
Journal of Oral Medicine and Pain
2015 .12
-
Pulp stones: any relevance with the levels of serum calcium, parathyroid hormone, vitamin D and uric acid
Restorative Dentistry and Endodontics
2024 .05
-
Aspartate aminotransferase activity in the pulp of teeth treated for 6 months with fixed orthodontic appliances
대한치과교정학회지
2015 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0