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Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats
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천마 추출물이 알코올을 투여한 흰쥐의 간 기능 및 알코올 대사에 미치는 영향

논문 기본 정보

Type
Academic journal
Author
Park, Soon-Ja (대구한의대학교 대학원 한방식품학과) Kang, Ju-Hyeon (대구한의대학교 대학원 한방식품학과) Kong, Hyun-Joo (대구한의대학교 한방식품조리영양학부) Hwang, Su-Jung (대구한의대학교 한방식품조리영양학부) Jang, Jung-Hyeon (부산동의과학대학교 피부미용계열) Yang, Kyung-Mi (대구한의대학교 한방식품조리영양학부)
Journal
Korean Society of Food and Cookery Science 한국식품조리과학회지 한국식품조리과학회지 제32권 제6호 KCI Accredited Journals
Published
2016.1
Pages
818 - 827 (10page)

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Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats
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Research history (3)

2018

천마 및 천마혼합 추출물의 생리활성과 알코올대사효소 활성 분석
박순자 ,  공현주 ,  황경희 and others 1 동아시아식생활학회 학술발표대회논문집 2018.06 Proceeding

2017

박순자 한방식품학과 2017.01 Thesis

2016

Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats
Pa ,  k ,  Soon-Ja and others 10 한국식품조리과학회지 2016.01 Academic journal
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Abstract· Keywords

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Purpose: This study was conducted to investigate the effect of freeze-dried Gastrodiae rhizoma powder (GR) on the liver function and alcohol metabolism in alcohol treated rats. Methods: The rats were administered various concentrations of GR (100 mg, 200 mg, 300 mg/kg B.W.) for 3 days 1 hour before 50% (v/v) ethanol (3 g/kg B.W.) administration. Two tests focusing on liver function and alcohol metabolism in acute alcohol treatment were carried out. Results: Glutamic oxaloacetic transaminase activity was significantly increased by alcohol treatment, and was decreased by 100 mg GR administration. Acute ethanol treatment led to significant increase in alcohol and acetaldehyde levels of serum and liver. However, 100 mg GR administration led to a significant reduction in increased alcohol level in the serum with decreased alcohol dehydrogenase (ADH) activity and increased acetaldehyde level in liver was significantly reduced by three levels. Conclusion: These results suggest that GR can be effective in enhancing liver function and alcohol metabolism in the alcohol-treated rats. Studies on the appropriate dosage of GR should further be developed to treat alcohol detoxification and stimulate liver function.
#Gastrodiae rhizoma #ethanol #liver function #acetaldehyde #ADH

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References (39)

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최근호 / 2011 / 급성 알코올 중독에서 헛개나무 추출물을 포함한 식품 조성물의 보호 효과 / 한국식품영양과학회지 40(8):1107~1112 dbpia 정용일 / 2009 / 알코올성 간 손상을 유발한 흰쥐에 대한 고 분지아미노산 함유 옥수수 단백가수물의 간 기능 보호효과 / 한국식품과학회지 41(6):706~711 dbpia Das SK / 2007 / Alcohol-induced oxidative stress / Life Sci 81(3):177~187 google schola Gill K / 1996 / The regulation of alcohol consumption in rats : The role of alcohol-metabolizing enzymes-catalase and aldehyde dehydrogenase / Alcohol 13(4):347~353 google schola 한찬규 / 2014 / 오미자농축액이 급성주정중독량 및 장기간 주정을 투여한 흰쥐의 혈중 알코올 분해율과 간 기능 보호에 미치는 영향 / 한국식품영양과학회지 43(8):1139~1147 dbpia

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