지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cosmetic ingredients significantly influence the skin microbiome. Alcohols are commonly used in cosmetics as moisturizers, preservatives, or multifunctional excipients, but their impact on the skin microbiome remains poorly understood. This study investigated the effects of cosmetic alcohols on typical skin- resident bacteria. Nine skin-resident bacteria, including Gram- positive (G+) and Gram-negative (G-) strains, as well as three common pathogens, were tested. The minimum inhibitory concentration (MIC) and median inhibitory concentration (IC<sub>50</sub>) of six alcohols were determined using the broth micro- dilution method. Results showed that G+ bacteria had higher MICs and greater alcohol tolerance than G- bacteria. Notably, Cutibacterium acnes, a G+ bacterium, displayed lower MICs and higher sensitivity to alcohols. Additionally, varying sensitivities among strains of the same species were observed, underscoring significant intra-species variability. These findings suggest that alcohols at concentrations sufficient to inhibit pathogenic bacteria may also disrupt the skin microbiome by inhibiting resident microflora. Therefore, the impact of cosmetic formulations on the skin microbiome, particularly their compatibility with C. acnes, must be carefully considered. Our results provided a good indication that we should pay attention to the impact of cosmetic ingredients on the skin microbiome, such as alcohols, preservatives, and surfactants.
목차
Materials and Methods
Results
Discussion
References
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