지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제3호
- 발행연도
- 2004.1
- 수록면
- 273 - 277 (5page)
이용수
초록· 키워드
오류제보하기
In previous studies for the development of new anticonvulsants, we found that N-Cbz-$\alpha$-amino-N-alkylsuccinimides exhibited significant anticonvulsant activities in the Maximal electroshock seizure (MES) and Pentylenetetrazole induced seizure (PTZ) tests, and also their anticonvulsant activities were dependent on the N-alkyl substituents existent in their structures. Based on these estimations, N-Cbz-$\alpha$-amino-N-hydroxysuccinimide and various N-Cbz-$\alpha$-amino-N-alkoxysuccinimides were prepared in order to develop more active anticonvulsants and to examine the effects of N-hydoxy or N-alkoxy groups on their anticonvulsant activities. The (R)-or (S)-N-Cbz-$\alpha$-amino-N-hydroxysuccinimide and N-Cbz-$\alpha$-amino-N-alkoxysuccinimides were prepared from the corresponding (R)-or (S)-N-Cbz-aspartic acid through the known synthetic procedures. Their anticonvulsant activities in the MES and PTZ test were evaluated. All of these compounds except 3a showed significant anticonvulsant activities against the PTZ test, but these compounds were not active in the MES test. The most active compound in the PTZ test was (R)-N-Cbz-$\alpha$-amino-N-benzyloxysuccinimide (ED$_{50}$=62.5 mg/kg). In addition, the anti-convulsant activities of these compounds were dependent on their N-substited groups. The order of anticonvulsant activity against the PTZ test, as judged from the ED50 values for (R) series was N-benzyloxy > N-hydroxy > N-isopropoxy > N-methoxy > N-ethoxy; for the (S) series N-ethoxy > N-benzyloxy > N-methoxy > N-isopropoxy.y.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Effect of N-Substituted Alkyl Groups on Anticonvulsant Activities of N-Cbz-$\alpha$-amino-N-alkylglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Synthesis and Anticonvulsant Evaluation of a Series of $N-Cbz-\alpha-aminoglutarimides$
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Synthesis and Anticonvulsant Evaluations of N-Cbz-$\alpha$-amino-N- alkoxyglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
The Effect of N-Alkyloxycarbonyl Group on the Anticonvulsant Activities of N-Alkyloxycarbonyl-${\alpha}$-aminoglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
The Effect of N-Alkyloxycarbonyl Group on the Anticonvulsant Activities of N-Alkyloxycarbonyl-alpha-amino-N-methylsuccinimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
Synthesis and Anticonvulsant Evaluation of 6-Amino-1,4-oxazepane-3,5-dione Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Synthesis and Anticonvulsant Activities of N-Cbz-${\alpha}$-aminoglutarimidooxy Carboxylate Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
The Effect of N-Substituted Alkyl Groups on the Anticonvulsant Activities of N-Cbz-${\alpha}$-amino-N-alkylsuccinimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
N-Acyl-$\alpha$-aminoglutarimide계 화합물의 항경련 활성에 대한 N-Acyl기의 영향
약학회지
2001 .01
-
Synthesis and anticonvulsant evaluation of a series of (R)-and (S)-N-Cbz-.alpha.-aminosuccinmide and their structure activity relationship
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Effects of Anticonvulsants on Acute and Tonic Pains in the Rat
대한생리학회지
1996 .01
-
Significance of Dextromethorphan Molecule for Anticonvulsant Effect : Metabolizing Process is Not Necessary for Dextromethorphan’s Anticonvulsant Effect
Laboratory Animal Research
2002 .03
-
Synthesis and Hypnotic Activities of N-Cbz-$\alpha$-aminoglutarimidooxy Carboxylate Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Synthesis of 8-Alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and Evaluation of their Anticonvulsant Properties
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Vitamin D Levels in Children and Adolescents with Antiepileptic Drug Treatment
Yonsei Medical Journal
2014 .01
-
Synthesis and Pharmacological Screening for Muscle Relaxant, Anticonvulsant, and Sedative Activities of Certain Organic Compounds Produced by Michael Addition
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Synthesis and Anticonvulsant Evaluation of N-Substituted-Isoindolinedione Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
항경련제가 혈청 구리와 아연 농도에 미치는 영향
Clinical and Experimental Pediatrics
2005 .01
-
Carbamazepine에 의한 기관분기부하 림푸절 종대와 호산구성 폐렴이 동반된 Anticonvulsant Hypersensitivity Syndrome 1예
Tuberculosis and Respiratory Diseases
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0