지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제19권 제4호
- 발행연도
- 1996.1
- 수록면
- 312 - 316 (5page)
이용수
초록· 키워드
오류제보하기
A series of N-Cbz${alpha}$-aminosucinimides (1), combining common moieties of various anticonvulsants such as N-CO-C-N and cyclic imide in a single molecule, were synthesized from the corresponding (R)- and (S)-N-Cbz-aspartic acid (2). And their in vivo anticonvulsant evaluations in MES and PTZ test were investigated. And also the rotorod test for neurotoxicity was investigated. All the tested compounds (1), except 1c and 1f, showed significant anticonvulsant activities in both MES and PTZ test. And the most active compound among them in MES test was (R)-N-Cbz-${alpha}$-amino-N-methylsuccinimide (1b) $(ED_50/=52.5 mg/kg)$ and (S)-N-Cbz-aminosuccinimide((1d) was most active in PTZ test $(ED_50/=78.1 mg/kg)$. And the $TD_50$ values of the tested compounds were above 117.5 mg/kg. These pharmacological data were comparable to those of currently available anticonvulsants. And also we found that the pharmacological effects were dependent on their N-substituted alkyl chains and their stereochemistry.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Synthesis and Anticonvulsant Evaluation of $N-Cbz-\alpha-amino-N-alkoxysuccinimides$
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Synthesis and Anticonvulsant Evaluation of a Series of $N-Cbz-\alpha-aminoglutarimides$
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
The Effect of N-Substituted Alkyl Groups on Anticonvulsant Activities of N-Cbz-$\alpha$-amino-N-alkylglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
The Effect of N-Alkyloxycarbonyl Group on the Anticonvulsant Activities of N-Alkyloxycarbonyl-${\alpha}$-aminoglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
Synthesis and Anticonvulsant Evaluations of N-Cbz-$\alpha$-amino-N- alkoxyglutarimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
The Effect of N-Substituted Alkyl Groups on the Anticonvulsant Activities of N-Cbz-${\alpha}$-amino-N-alkylsuccinimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Synthesis and Anticonvulsant Activities of N-Cbz-${\alpha}$-aminoglutarimidooxy Carboxylate Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
경련과 자연발생 엽상뇌출혈의 임상적연구
Annals of Clinical Neurophysiology
2002 .01
-
신생아 경련성 질환의 항경련제 요법
Neonatal medicine
2009 .01
-
Synthesis and Anticonvulsant Evaluation of 6-Amino-1,4-oxazepane-3,5-dione Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
항경련제를 복용하고 있는 지적장애 환자의 외래전신마취 하 치과치료 후 합병증 발생 조사 연구
Journal of dental anesthesia and pain medicine
2014 .01
-
Mental Change, Seizure
대한외과학회 학술대회 초록집
2019 .10
-
Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?
Clinical and Experimental Pediatrics
2014 .01
-
경미한 감염과 관련된 유발성 경련과 열성 경련의 비교
Clinical and Experimental Pediatrics
2007 .01
-
N-Acyl-$\alpha$-aminoglutarimide계 화합물의 항경련 활성에 대한 N-Acyl기의 영향
약학회지
2001 .01
-
The Effect of N-Alkyloxycarbonyl Group on the Anticonvulsant Activities of N-Alkyloxycarbonyl-alpha-amino-N-methylsuccinimides
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
국내 신생아 경련에 대한 보고
Clinical and Experimental Pediatrics
2009 .01
-
신생아 경련의 진단
Clinical and Experimental Pediatrics
2009 .01
-
뇌내(腦內) Norepinephrine함량변화(含量變化)와 Clonazepam의 항경련효과(抗痙攣效果)에 미치는 6-Hydroxydopamine의 영향(影響)
약학회지
1988 .01
-
Seizures in Patients with Brain Tumors
대한신경외과학회지
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0