지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 417 - 421 (5page)
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초록· 키워드
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Purpose: This study was to evaluate the relationship of 25(OH)D3 levels with anticonvulsantuse and other possible factors in epileptic children and adolescents. Materials and Methods: We studied 143 patients with epilepsy (90 boys, 53 girls; 11.21±4.49 years), who had been treated with anticonvulsants for more than 1 year. Patients who had taken multiple vitamins before the blood test and those who have the limitation of physical activity (wheelchair-bound) were excluded from the study. We evaluated the difference in vitamin D status according to the type and number of anticonvulsants taken and other factors such as gender, age, intelligence and seizure variables. Results: For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0.03). 25(OH)D3 levels were lower in patientswho had taken anticonvulsants for more than 2 years as compared to those who had taken them for less than 2 years (p=0.03). Those taking oxcarbazepine had significantly lower vitamin D levels than patients taking valproic acid (p=0.01). However, no effects of number of anticonvulsants taken were detectable. More than two-thirds of the patients were diagnosed with osteopenia or osteoporosisin patients showing either vitamin D insufficiency or deficiency. Conclusion: The possibility of vitamin D deficiency can be considered in pediatric patients takinganticonvulsants if they have mental retardation or developmental delay or if they have been taking anticonvulsants for more than 2 years or taking hepatic enzymeinducing drugs.
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참고문헌 (18)
참고문헌 신청
Baker MR / 1980 / The decline in vitamin D status with age / Age Ageing 9 : 249 ~ 252
Bell RD / 1979 / Effect of phenytoin on bone and vitamin D metabolism / Ann Neurol 5 : 374 ~ 378
Bischoff-Ferrari HA / 2006 / Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes / Am J Clin Nutr 84 : 18 ~ 28
Cansu A / 2008 / Evaluation of bone turnover in epileptic children using oxcarbazepine / Pediatr Neurol 39 : 266 ~ 271
Grant WB / 2005 / Benefits and requirements of vitamin D for optimal health: a review / Altern Med Rev 10 : 94 ~ 111
Bell RD / 1979 / Effect of phenytoin on bone and vitamin D metabolism / Ann Neurol 5 : 374 ~ 378
Bischoff-Ferrari HA / 2006 / Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes / Am J Clin Nutr 84 : 18 ~ 28
Cansu A / 2008 / Evaluation of bone turnover in epileptic children using oxcarbazepine / Pediatr Neurol 39 : 266 ~ 271
Grant WB / 2005 / Benefits and requirements of vitamin D for optimal health: a review / Altern Med Rev 10 : 94 ~ 111
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