지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제4호
- 발행연도
- 2004.1
- 수록면
- 442 - 448 (7page)
이용수
초록· 키워드
오류제보하기
Wogonin (5,7-dihydroxy-8-methoxyflavone) is a down-regulator of cyclooxygenase-2 and inducible nitric oxide synthase expression, contributing to anti-inflammatory activity in vivo. For further characterization of modulatory activity on ploinflammatory gene expression in vivo, the effect of wogonin was examined in this experiment using animal models of skin inflammation. By topical application, wogonin inhibited an edematic response as well as ploinflammatory gene expression against contact dermatitis In mice. Wogonin inhibited ear edema ($19.4-22.6\%$) at doses of $50-200\;{\mu}g$/ear and down-regulated interleukin-$1{\beta}$ induction ($23.1\%$) at $200{\mu}g$/ear in phenol-induced simple irritation. Wogonin ($2{\times}50-2{\times}200{\mu}g$/ear) also inhibited edematic response ($51.2-43.9\%$) and down-regulated ploinflammatory gene expression of cyclooxygenase-2, interleukin-$1{\beta}$, interferon-$\gamma$, intercellular adhesion molecule-1 and inducible nitric oxide synthase with some different sensitivity against picryl chloride-induced delayed hypersensitivity reaction. All these results clearly demonstrate that wogonin is a down-regulator of ploinflammatory gene expression in animal models of skin inflammation. Therefore, wogonin may have potential for a new anti-inflammatory agent against skin inflammation.
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Histopathological Comparison of Animal Models of Skin Inflammation and Inhibition of the Inflammatory Responses by Plant Flavonoid, Wogonin
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
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Suppression of Cyclooxygenase-2 Expression of Skin Fibroblasts by Wogonin, a Plant Flavone from Scutellaria Radix
한국응용약물학회 추계학술발표논문집
2003 .01
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Structure and Antiinflammatory Activity Relationships of Wogonin Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Synthetic Wogonin Derivatives Suppress Lipopolysaccharide-Induced Nitric Oxide Production and Hydrogen Peroxide-Induced Cytotoxicity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Effects of Wogonin, a Plant Flavone from Scutellaria Radix, on Skin Inflammation:In Vivo Regulation of Inflammation-associated Gene Expression
대한약학회 학술대회
2003 .01
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Neuroprotective Effect of Wogonin： Potential Roles of Inflammatory Cytokines
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Wogonin and Its Analogs
대한약학회 학술대회
2003 .01
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Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix
대한약학회 학술대회
2001 .01
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Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE Production from LPS-Induced RAW 264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
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Flavonoid and Skin Inflammation
한국응용약물학회 추계학술발표논문집
2007 .01
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Suppression of Cyclooxygenase-2 and inducible Nitric Oxide Synthase Enzyme Induction from Lipopolysaccharide-induced RAW 264.7 by Wogonin, a Plant Flavone from Scutellaria Radix
대한약학회 학술대회
2000 .01
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .08
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Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
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Wogonin, a flavone from Scutellaria radix, inhibits nitric oxide production from RAW 264.7 cells
한국응용약물학회 추계학술발표논문집
1998 .01
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .01
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[지상 14] Wogonin Suppresses Ethanol-induced caspase-11 expression and cell death in N2a neuroblastoma cells
대한체질인류학회 학술대회 연제 초록
2005 .05
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Different Effects of Flavonoids in Scutellaria baicalensis on Anxious and Sedative Behaviors
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
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Molecular Events on Experimental Skin Inflammation and Modulation by Topical Anti-inflammatory Flavonoids
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2007 .01
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